Art

J-GLOBAL ID：201102233398300178   Reference number：11A1431712

A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity

アセトアミノフェン誘発肝毒性の機序的洞察のための1H NMRに基づくメタボロミクス的アプローチ

Author (5)： FUKUHARA Kiyoshi (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  OHNO Akiko (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  ANDO Yosuke (Medical Safety Res. Laboratories, Daiichi Sankyo Co., Ltd.) ,  YAMOTO Takashi (Medical Safety Res. Laboratories, Daiichi Sankyo Co., Ltd.) ,  OKUDA Haruhiro (Div. of Organic Chemistry, National Inst. of Health Sciences)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 26  Issue： 4  Page： 399-406 (J-STAGE)  Publication year： 2011 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： 酵素誘導物質

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Toxicology in general  (GZ01000K)

Substance index (2)： Acetaminophen ,  Phenobarbital

Reference (23)：

• 1) Hinson, J. A., Pumford, N. R. and Roberts, D. W.: Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts. Drug Metab. Rev., 27: 73–92 (1995).
• 2) Bessems, J. G. and Vermeulen, N. P.: Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol., 31: 55–138 (2001).
• 3) Jollow, D. J., Thorgeirsson, S. S., Potter, W. Z., Hashimoto, M. and Mitchell, J. R.: Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology, 12: 251–271 (1974).
• 4) Dahlin, D. C., Miwa, G. T., Lu, A. Y. and Nelson, S. D.: N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. USA, 81: 1327–1331 (1984).
• 5) Laine, J. E., Auriola, S., Pasanen, M. and Juvonen, R. O.: Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica, 39: 11–21 (2009).

Terms in the title (6)： アセトアミノフェン ,  誘発 ,  肝毒性 ,  洞察 ,  NMR ,  メタボロミクス