Art

J-GLOBAL ID：201102233398300178   Reference number：11A1431712

A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity

アセトアミノフェン誘発肝毒性の機序的洞察のための1H NMRに基づくメタボロミクス的アプローチ

Author (5)： FUKUHARA Kiyoshi (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  OHNO Akiko (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  ANDO Yosuke (Medical Safety Res. Laboratories, Daiichi Sankyo Co., Ltd.) ,  YAMOTO Takashi (Medical Safety Res. Laboratories, Daiichi Sankyo Co., Ltd.) ,  OKUDA Haruhiro (Div. of Organic Chemistry, National Inst. of Health Sciences)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 26  Issue： 4  Page： 399-406 (J-STAGE)  Publication year： 2011 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： 酵素誘導物質

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=11A1431712&from=J-GLOBAL&jstjournalNo=X0758A") }}

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Toxicology in general  (GZ01000K)

Substance index (2)： Acetaminophen ,  Phenobarbital

Reference (23)：

• 1) Hinson, J. A., Pumford, N. R. and Roberts, D. W.: Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts. Drug Metab. Rev., 27: 73–92 (1995).
• 2) Bessems, J. G. and Vermeulen, N. P.: Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol., 31: 55–138 (2001).
• 3) Jollow, D. J., Thorgeirsson, S. S., Potter, W. Z., Hashimoto, M. and Mitchell, J. R.: Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology, 12: 251–271 (1974).
• 4) Dahlin, D. C., Miwa, G. T., Lu, A. Y. and Nelson, S. D.: N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. USA, 81: 1327–1331 (1984).
• 5) Laine, J. E., Auriola, S., Pasanen, M. and Juvonen, R. O.: Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica, 39: 11–21 (2009).

Terms in the title (6)： アセトアミノフェン ,  誘発 ,  肝毒性 ,  洞察 ,  NMR ,  メタボロミクス