Art

J-GLOBAL ID：201102245531569604   Reference number：11A0473533

Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Decreases Systolic Blood Pressure in Japanese Hypertensive Patients with Type 2 Diabetes

ジペプチジルペプチダーゼ4阻害剤であるシタグリプチンは,2型糖尿病を有する日本人患者における収縮期血圧を下げる

Author (9)： OGAWA Susumu (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  OGAWA Susumu (Center for the Advancement of Higher Education, Tohoku Univ.) ,  ISHIKI Mikihito (Iwate Prefectural Takata Hospital) ,  NAKO Kazuhiro (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  OKAMURA Masashi (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  OKAMURA Masashi (United Centers for Advanced Res. and Translational Medicine, Tohoku Univ. Graduate School of Medicine) ,  SENDA Miho (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  MORI Takefumi (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  ITO Sadayoshi (Div. of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ. Graduate School of Medicine)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 223  Issue： 2  Page： 133-135 (J-STAGE)  Publication year： 2011 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： proteinase inhibitor ,...
Semi thesaurus term： *non-insulin-dependent diabetes mellitus ,...

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JST classification (1)： Drug therapy(=pharmacotherapy)for endocrine diseases  (GL05020S)

Substance index (1)： Sitagliptin

Reference (12)：

• ANDERSON, E. A. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension. 1992, 19, 621-627
• ANDERSON, E. A. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J. Clin. Invest. 1991, 87, 2246-2252
• FERREIRA, L. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators Inflamm. 2010, 2010, 592760
• GUTZWILLER, J. P. Glucagon-like peptide-1 is involved in sodium and water homeostasis in humans. Digestion. 2006, 73, 142-150
• GUTZWILLER, J. P. Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men. J. Clin. Endocrinol. Metab. 2004, 89, 3055-3061

Terms in the title (7)： ジペプチジルペプチダーゼ4 ,  阻害剤 ,  シタグリプチン ,  2型糖尿病 ,  日本人 ,  患者 ,  収縮期血圧