Art

J-GLOBAL ID：201102249200521224   Reference number：11A1368631

Development of an Alternative Test for Skin Sensitization Using a Three-dimensional Human Skin Model Consisting of Dendritic Cells, Keratinocytes and Fibroblasts

樹状細胞,角化細胞および線維芽細胞から成る三次元ヒト皮膚モデルを用いた皮膚感作の代替試験の開発

Author (4)： UCHINO Tadashi (National Inst. Health Sci., Tokyo, JPN) ,  TAKEZAWA Toshiaki (National Inst. Agrobiological Sci., Ibaraki, JPN) ,  IKARASHI Yoshiaki (National Inst. Health Sci., Tokyo, JPN) ,  NISHIMURA Tetsuji (National Inst. Health Sci., Tokyo, JPN)
Material： Alternatives to Animal Testing and Experimentation  (AATEX)
Volume： 16  Issue： 1  Page： 1-8  Publication year： Jun. 30, 2011 
JST Material Number： L5507A  ISSN： 1344-0411  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *skin reaction ,...
Semi thesaurus term： IL14 ,...

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JST classification (2)： Basic dermatology  (GF01020Y) ,  Cosmetics  (YG03030S)

Reference (19)：

• Aeby, P., Ashikaga, T., Bessou-Touya, S., Schepky, A., Gerberick, F., Kern, P., Marrec-Fairly, M., Maxwell, G., Ovigne, J.-M., Sakaguchi, H., Reisinger, K., Tailhardat, M., Martinozzi-Teissier, S. and Winkler, P., (2010) Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program, Toxicol In Vitro 24, 1465-73.
• Ashikaga, T., Sakaguchi, H., Okamoto, K., Mizuno, M., Sato, J., Yamada, T., Yoshida, M., Ota, N., Hasegawa, S., Kodama, T., Okamoto, Y., Kuwahara, H., Kosaka, N., Sono, S. and Ohno, Y. (2008) Assessment of the human cell line activation test (h-CLAT) for Skin Sensitization; results of the first Japanese inter-laboratory study, AATEX, 13, 27-35.
• Ashikaga, T., Sakaguchi, H., Sono, S., Kosaka, N., Makie, I., Nukada, Y., Miyazawa, M., Ito, Y., Nishiyama, N. and Itagaki, H. (2010) A comparative evaluation of in vitro skin sensitization tests: the human cell line activation test (h-CLAT) versus the local lymph node assay (LLNA), Altern. Lab. Anim., 38, 275-284.
• Ashikaga, T., Yoshida, Y., Hirota, M., Yoneyama, K., Itagaki, H., Sakaguchi, H., Miyazawa, M., Ito, Y., Suzuki, H. and Toyoda, H. (2006) Development of an in vitro skin sensitization tests using human cell lines; human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol, Toxicol. in Vitro 20, 767-773.
• Bernhofer, L.P., Seiberg, M. and Martin, K. M. (1999) The influence of the response of skin equivalent systems to topically applied consumer products by epithelial-mesenchymal interactions, Toxicol. in Vitro, 13, 219-229.

Terms in the title (9)： 樹状細胞 ,  角化細胞 ,  線維芽細胞 ,  ヒト ,  皮膚モデル ,  皮膚感作 ,  代替 ,  試験 ,  開発