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J-GLOBAL ID：201102250740141658   Reference number：11A0944688

Cilostazol Inhibits Cytokine-Induced Tetrahydrobiopterin Biosynthesis in Human Umbilical Vein Endothelial Cells

シロスタゾールはヒト臍帯静脈内皮細胞でサイトカイン誘導テトラヒドロビオプテリン生合成を阻害する

Author (8)： SHIRAISHI Hiroaki (Dep. of Pharmacology, Fujita Health Univ. School of Medicine.) ,  IKEMOTO Kazuhisa (Dep. of Pharmacology, Fujita Health Univ. School of Medicine.) ,  TADA Shin (Dep. of Obstetrics and Gynecology, Fujita Health Univ. School of Medicine.) ,  UDAGAWA Yasuhiro (Dep. of Obstetrics and Gynecology, Fujita Health Univ. School of Medicine.) ,  OHTSUKI Masatsugu (Dep. of Internal Medicine, Fujita Health Univ. School of Medicine.) ,  SUMI-ICHINOSE Chiho (Dep. of Pharmacology, Fujita Health Univ. School of Medicine.) ,  KONDO Kazunao (Dep. of Pharmacology, Fujita Health Univ. School of Medicine.) ,  NOMURA Takahide (Dep. of Pharmacology, Fujita Health Univ. School of Medicine.)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 18  Issue： 4  Page： 312-317 (J-STAGE)  Publication year： 2011 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： vascular endothelial cell ,...
Semi thesaurus term： GTP cyclohydrolase I ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of drugs acting on blood and body fluid  (GW14010M)

Substance index (2)： Cilostazol ,  Tetrahydrobiopterin

Reference (25)：

• 1) Ross R: Atherosclerosisan inflammatory disease. N Engl J Med, 1999; 340: 115-126
• 2) Mori D, Ishii H, Kojima C, Nitta N, Nakajima K, Yoshida M: Cilostazol inhibits monocytic cell adhesion to vascular endothelium via upregulation of cAMP. J Athero-scler Thromb, 2007; 14: 213-218
• 3) Iwamoto T, Kin K, Miyazaki K, Shin K, Takasaki M: Recovery of platelet function after withdrawal of cilostazol administered orally for a long period. J Atheroscler Thromb, 2003; 10: 348-354
• 4) Oida K, Ebata K, Kanehara H, Suzuki J, Miyamori I: Effect of cilostazol on impaired vasodilatory response of the brachial artery to ischemia in smokers. J Atheroscler Thromb, 2003; 10: 93-98
• 5) Aoki C, Hattori Y, Tomizawa A, Jojima T, Kasai K: Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo. J Atheroscler Thromb, 2010; 17: 503-509

Terms in the title (7)： シロスタゾール ,  ヒト臍帯静脈内皮細胞 ,  サイトカイン ,  誘導 ,  テトラヒドロビオプテリン ,  生合成 ,  阻害