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J-GLOBAL ID：201102268203687241   Reference number：11A1536149

Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells

トロンビン刺激内皮細胞中のRhoA/Rac1依存性シグナル経路において膜型マトリックスメタロプロテアーゼ1(MT1-MMP)の果たす極めて重要な役割

Author (11)： ANDO Katsuya (Dep. of Cardiology and Hematology, Fukushima Medical Univ.) ,  ISHIBASHI Toshiyuki (Dep. of Cardiology and Hematology, Fukushima Medical Univ.) ,  ISHIBASHI Toshiyuki (Dep. of Cardiovascular Medicine, Ohara General Hospital Medical Center.) ,  OHKAWARA Hiroshi (Dep. of Cardiology and Hematology, Fukushima Medical Univ.) ,  INOUE Nobutaka (Dep. of Cardiovascular Medicine, Kobe Rosai Hospital.) ,  SUGIMOTO Koichi (Dep. of Cardiology and Hematology, Fukushima Medical Univ.) ,  UEKITA Hironori (Dep. of Cardiology and Hematology, Fukushima Medical Univ.) ,  HU Chengjun (Dep. of Anatomy & Embryology, Wuhan Univ. School of Medicine.) ,  OKAMOTO Yasuo (Dep. of Physiology, Kanazawa Univ. Graduate School of Medicine.) ,  TAKUWA Yoh (Dep. of Physiology, Kanazawa Univ. Graduate School of Medicine.) ,  TAKEISHI Yasuchika (Dep. of Cardiology and Hematology, Fukushima Medical Univ.)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 18  Issue： 9  Page： 762-773 (J-STAGE)  Publication year： 2011 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *matrix metalloproteinase ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Reference (33)：

• 1) Coughlin SR: Thrombin signalling and protease-activated receptors. Nature, 2000; 407: 258-264
• 2) Eto M, Barandier C, Rathgeb L, Kozai T, Joch H, Yang Z, Luscher TF: Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase. Circ Res, 2001; 89: 583-590
• 3) Van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW: Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res, 2000; 87: 335-340
• 4) Hirano K, Kanaide H: Role of protease-activated Recep-tors in the vascular system. J Atheroscler Thromb, 2003; 10: 211-225
• 5) Viswambharan H, Ming XF, Zhu S, Hubsch A, Lerch P, Vergeres G, Rusconi S, Yang Z: Reconstituted high-den-sity lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase. Circ Res, 2004; 94: 918-925

Terms in the title (10)： トロンビン ,  刺激 ,  内皮細胞 ,  RhoA ,  Rac1 ,  依存性 ,  シグナル経路 ,  マトリックスメタロプロテアーゼ ,  MT1-MMP ,  役割