Art

J-GLOBAL ID：201102291757860648   Reference number：11A1000119

A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-β synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth

合成NOD2アゴニスト,ムラミルジペプチド(MDP)-Lys(L18)とIFN-βは相乗的にIL-12産生増加を伴う樹状細胞の成熟を誘導し,メラノーマの増殖を抑制する

Author (5)： FUJIMURA Taku (Dep. of Dermatology, Tohoku Univ. Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, JPN) ,  YAMASAKI Kenshi (Dep. of Dermatology, Tohoku Univ. Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, JPN) ,  HIDAKA Takanori (Dep. of Dermatology, Tohoku Univ. Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, JPN) ,  ITO Yumiko (Dep. of Dermatology, Tohoku Univ. Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, JPN) ,  AIBA Setsuya (Dep. of Dermatology, Tohoku Univ. Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, JPN)
Material： Journal of Dermatological Science  (J Dermatol Sci)
Volume： 62  Issue： 2  Page： 107-115  Publication year： May. 2011 
JST Material Number： W1280A  ISSN： 0923-1811  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *melanoma ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=11A1000119&from=J-GLOBAL&jstjournalNo=W1280A") }}

JST classification (2)： Skin tumors(=neoplasms)  (GF04000X) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (1)： Muramyl dipeptide

Reference (31)：

• MIYAKOSHI, J. Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons. Cancer Res. 1990, 50, 278-283
• JAMES, CD. Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. Cancer Res. 1991, 51, 1684-1688
• YOSHIDA, J. Interferon-beta gene therapy for cancer : basic research to clinical application. Cancer Sci. 2004, 95, 858-865
• CREASEY, AA. Growth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetase. Mol Cell Biol. 1983, 3, 780-786
• SARNA, GP. Phase II study of betaseron (beta ser17-interferon) as treatment of advanced malignant melanoma. J Biol Response Mod. 1987, 6, 375-378

Terms in the title (11)： NOD2 ,  アゴニスト ,  ムラミルジペプチド ,  Lys ,  IFN ,  IL-12 ,  樹状細胞 ,  成熟 ,  誘導 ,  メラノーマ ,  増殖