Art

J-GLOBAL ID：201102295652725503   Reference number：11A1001599

Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells

ヒト肝癌細胞の球状培養によるMDR1蛋白質を介した薬剤排出活性の増強

Author (3)： OSHIKATA Ayumi ,  MATSUSHITA Taku ,  UEOKA Ryuichi
Material： Journal of Bioscience and Bioengineering
Volume： 111  Issue： 5  Page： 590-593  Publication year： May. 2011 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： HepG2 cell ,...
Semi thesaurus term： poly(L-glutamic acid) ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=11A1001599&from=J-GLOBAL&jstjournalNo=G0535B") }}

JST classification (4)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Transport of cell membrane  (EF04020R) ,  Biological function  (EB03040U)

Substance index (3)： Doxorubicin ,  Epirubicin ,  Fluorouracil

Reference (20)：

• GOTTESMAN, M. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993, 62, 385-427
• DEAN, M. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 2001, 42, 1007-1017
• TSURUO, T. Molecular cancer therapeutics : recent progress and targets in drug resistance. Intern. Med. 2003, 42, 237-243
• TATSUTA, T. Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 1992, 267, 20383-20391
• TSURUO, T. Molecular targeting therapy of cancer : drug resistance, apoptosis and survival signal. Cancer Sci. 2003, 94, 15-21

Terms in the title (9)： ヒト ,  肝癌細胞 ,  球状 ,  培養 ,  MDR1 ,  蛋白質 ,  薬剤 ,  活性 ,  増強