Ishiura Shoichi

イシウラショウイチ | Ishiura Shoichi

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/10158743

Research field (6)： Neurology , Functional biochemistry , Medical biochemistry , Structural biochemistry , Experimental psychology , Neuroscience - general

Research keywords (30)：プロテア-ゼ , アルツハイマ-病 , 筋ジストロフィ- , ADAM , アミロイド , パーフォリン , ジストロフィン , セクレターゼ , 情報伝達 , トリプレット・リピート , アミロイド前駆体 , 遺伝子 , タンパク分解 , 分泌 , キラーTリンパ球 , 神経科学 , 蛋白質 , 老化 , アポトーシス , 治療 , 脳神経疾患 , ミオパチー , MDC9 , C-キナ-ゼ , アミロイドβ蛋白質 , BACE , 脳 , ソ-ティング , BACE1 , 筋小胞体

Research theme for competitive and other funds (36)：

2013 - 2018 Molecular mechanism of polyalanine expansion disorders
2013 - 2015 Characterization of protein complex regulating glutamate-induced cell death
2013 - 2015 Fundamental research for understanding the working memory during locomotion
2010 - 2014 Theoretical and Practical Studies on the Crossing between Philosophy and Natural Science concerning Matter, Life, and Person
2006 - 2006 RIPによる細胞内情報伝達機構

2005 - 2006 アミノ酸ホモポリマー沈着による病態の階層モデル

2001 - 2004 Development and use of amyloid secretase modulators in Alzhaimer's disease.

2001 - 2003 ドーパミン関連遺伝子の効果のグラフィックベイズ分析

2001 - 2002 Shedding activity and physiological role of a newly-found ADAM family metalloprotease family

2000 - 2000 膜タンパク質セクレターゼ群の情報クロストーク

1999 - 2000 アルツハイマー病発症分子機構に関する総合的研究

1999 - 1999 メタロプロテアーゼによる細胞膜結合型蛋白質の分泌機構の解明

1998 - 1998 アルツハイマー病発症に関わる新規プロテアーゼの検索

1997 - 1998 Analysis of molecular mechanism of muscular dystrophy involving skeletal muscle-specific calpain and connectin

1996 - 1997 Isolation of signal molecules on the secretion of amyloid precursor

1996 - 1996 トリプレット・リピート伸長cDNA発現細胞とアポトーシス

1995 - 1996 Determination and regulation of half-life of the proteins

1995 - 1995 α-グルコシダーゼcDNA導入細胞を用いた糖原病II型の遺伝子治療

1995 - 1995 脳細胞選択死のモデルとしての異常cDNA発現細胞の解析

1994 - 1995 Secretion of amyloid precursor protein via signal transduction pathway

1993 - 1995 Structure and physiological function of novel calpain species

1992 - 1995 MOolecular mechanism of senile dementia. -summary of research-

1994 - 1994 バイオモジュレーターとしてのプロテアーゼ

1994 - 1994 転写因子の代謝と転写調節

1993 - 1993 ジストロフィンの欠損を補う胎児型アイソフォームの発現調節

1993 - 1993 転写因子の代謝と転写調節

1992 - 1993 Role of dystrophin-related protein in the pathogenesis of Duchenne muscular dystrophy.

1992 - 1992 アミロイド前駆体セクレターゼの同定,発現と制御

1992 - 1992 ジストロフィン類似蛋白質の発現と病態

1991 - 1992 Mechanism of down-regulation of protein kinase C and its implications in signal transduction

1990 - 1991 Manipulation of mdx mouse embryos

1989 - 1991 Molecular Pathological Analysis of the Duchenne Muscular Dystrophy Gene Product, Dystrophin.

1989 - 1990 Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex

1988 - 1989 Exploration of the mechanism of muscle necrosis in Polymyositis.

1987 - 1988 Studies on the mechanism of Cytotoxic T-lymphocyte (CTL)-mediated muscle breakdown

1986 - 1987 Chloroquine myopathy,its mechanism and treatment with cysteine proteinase inhibitor,EST

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Papers (307)：

Shoichi Ishiura, Taiji Yoshida. Plant-based vaccines for Alzheimer's disease. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2019. 95. 6. 290-294
Taiji Yoshida, Yuichiro Watanabe, Shoichi Ishiura. Production of the herb Ruta chalepensis L. expressing amyloid β-GFP fusion protein. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2019. 95. 6. 295-302
Satoshi Arai, Rókus Kriszt, Kazuki Harada, Liang-Sheng Looi, Shogo Matsuda, Devina Wongso, Satoshi Suo, Shoichi Ishiura, Yu-Hua Tseng, Michael Raghunath, et al. RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells. Angewandte Chemie (International ed. in English). 2018. 57. 34. 10873-10878
Hiroyuki Ishiura, Koichiro Doi, Jun Mitsui, Jun Yoshimura, Miho Kawabe Matsukawa, Asao Fujiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Yutaka Suzuki, et al. Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy. Nature genetics. 2018. 50. 4. 581-590
Yoichi Negishi, Yoko Endo-Takahashi, Shoichi Ishiura. Exon Skipping by Ultrasound-Enhanced Delivery of Morpholino with Bubble Liposomes for Myotonic Dystrophy Model Mice. Methods in molecular biology (Clifton, N.J.). 2018. 1828. 481-487

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MISC (87)：

Yoshihiro Kino, Jun Ichi Satoh, Shoichi Ishiura. Molecular mechanisms of myotonic dystrophy: RNA-mediated pathogenesis and rna-binding proteins. Myotonic Dystrophy: Disease Mechanism, Current Management and Therapeutic Development. 2018. 19-43
森亮太郎, 浅井将, 浅井将, 木村祥子, 川久保昂, 城谷圭朗, 城谷圭朗, 趙一夢, 石浦章一, 岩田修永, et al. ダウン症患者における早期アルツハイマー病発症とαセクレターゼ活性の関連解析. 日本生化学会大会(Web). 2016. 89th
二井勇人, 大沢智子, 蔡哲夫, 石浦章一, 富田泰輔. 家族性アルツハイマー病PS1変異の異常活性を回復させるサプレッサー変異の解析. 日本病態プロテアーゼ学会学術集会プログラム抄録集. 2015. 20th
穀内洋介, 紀嘉浩, Li Moy, 伊藤英樹, 中森雅之, 木村卓, 松村剛, 藤村晴俊, 貫名信行, 堀江稔, et al. Naチャネルのスプライシング異常が筋強直性ジストロフィーの心臓伝導障害に関与する. 臨床神経学. 2013. 53. 12. 1412-1412
ISHIURA Shoichi. Effect of rice-expressed amyloid β protein in the Tg2576 Alzheimer's disease transgenic mouse model. 2012. 36. 1. 1-4

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Work history (6)：

2022/04 - 現在 Doshisha University
2022/04 - 現在 Kyoto University of Advanced Science Institute of Interdisciplinary Research
2021/04 - 現在 Niigata University of Health and Welfare
2021/04 - 2022/03 Kyoto University of Advanced Science
2016/04 - 2021/03 同志社大学生命医科学部特別客員教授

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