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J-GLOBAL ID：201201039834530098   Update date: Mar. 06, 2024

KUMAMOTO TAKUYA

クマモト タクヤ | KUMAMOTO TAKUYA
Affiliation and department：
Hiroshima University

About Hiroshima University


Research field  (1)： Clinical pharmacy
Research keywords  (1)： Synthetic organic chemistry
Research theme for competitive and other funds  (13)：
  • 2022 - 2027 Development of multivalent PET tracers for the early diagnosis of Alzheimer's disease
  • 2023 - 2026 Development of dual-action antimicrobial agents effective against antimicrobial resistant bacteria
  • 2019 - 2024 Generation of highly functionalized naphthoquiones based on the mechanistic understanding of biosynthetic enzymes
  • 2019 - 2023 Studies towards total synthesis of anti-HIV conocurvone and construction of trimeric structure using benzyne intermediates
  • 2019 - 2022 Development of PET tracers for the imaging of microglial cells and their activities
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Papers (88)：
  • Takahiro Shirai*, Yusuke Migitera, Ryo Nakajima, and Takuya Kumamoto*. Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes Using Hydrosilane at Room Temperature. J Org Chem. 2024. 89. 4. 2787-2793
  • Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells. Front. Pharmacol., Sec. Neuropharmacology. 2023. 14. 1284586
  • Makoto Hashimoto, Susumu Watari, Takaaki Taguchi, Kazuki Ishikawa, Takuya Kumamoto, Susumu Okamoto, and KojiIchinose. Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction. Angew. Chem. Int. Ed. 2022. e202214400
  • Hiroki Miyake, Ryo Nakajima, and Takuya Kumamoto*. Asymmetric Total Synthesis of Brasiliquinones B and C via Oxidative Cyclization of a Hydroquinone-Silyl Enol Ether Hybrid. Journal of Organic Chemistry. 2022. 87. 18. 12491-12497
  • Takuya Kumamoto, Mika Kainuma, Azusa Takahashi, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi, Koji Ichinose. Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer. Molecules. 2021. 26. 21. 6397-6397
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MISC (104)：
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Patents (2)：
  • 誘導型一酸化窒素合成酵素(iNOS)を阻害するクマリン化合物
  • グアンジン化合物及びグアニジン化合物のポリマー固定化複合体
Books (3)：
  • Chapter 1. Recent Progress in Aryne Cycloaddition Reactions
    NOVA SCIENCE PUBLISHERS 2019 ISBN:9781536154207
  • <B>Superbases for Organic Synthesis</B>: Guanidines, Amidines, Phosphazenes and Related Organocatalysts
    2009
  • <B>Superbases for Organic Synthesis</B>: Guanidines, Amidines, Phosphazenes and Related Organocatalysts
    2009
Lectures and oral presentations  (54)：
  • Total Synthesis of Brasiliquinones
    (International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023 2023)
  • 温和な条件の不活性型オレフィンに対する還元的ヘック反応の開発
    (日本薬学会第143年会 2023)
  • 不活性型オレフィンに対する還元的ヘック反応の開発
    (第48回反応と合成の進歩シンポジウム実行委員会 2022)
  • Synthetic Studies toward Natural Xanthone Blennolides via Spirochromanones
    (ICPAC Kota Kinabalu 2022 2022)
  • Synthetic study toward natural chromenoquinone teretifolione B via chiral chromene synthesis
    (AIMECS 2021 13th AFMC International Medicinal Chemistry Symposium 2021)
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Works (6)：
  • シロキシジエンを用いる不斉 Diels-Alder 反応(ファルマシア 2001)
  • エチレンジアニオン等価体を用いたシクロプロパン化反応(ファルマシア 1995)
  • Guanidines in Organic Synthesis(Synthesis 2006)
  • 構造に混乱のある Kinamycin 類の化学(有機合成化学協会誌 2004)
  • 赤外線で有機化合物を見分ける(化学と教育2010)
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Education (6)：
  • - 1996 The University of Tokyo
  • - 1996 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1993 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1993 The University of Tokyo
  • - 1991 Kanazawa University Faculty of Pharmaceutical Sciences
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Professional career (1)：
  • 博士 (東京大学)
Work history (7)：
  • 2017/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
  • 2010/04 - 2017/03 Musashino University Professor
  • 2007/06 - 2010/03 Chiba University Associate Professor
  • 2005/04 - 2007/05 Chiba University Lecturer
  • 1997/04 - 2005/03 Chiba University Research Associate
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Committee career (7)：
  • 2019/09 - 2023/09 International Pharmacy Federation International Pharmacy Federation, Board of Pharmaceutical Sciences, Special Interest Group New Medicines, Chair
  • 2020/05 - 2021/05 有機合成化学協会中国四国支部 有機合成化学協会中国四国支部 支部幹事
  • 2016/04 - 2021/03 Pharmaceutical Society of Japan International Affairs
  • 2020/02 - 2021/02 日本薬学会中国四国支部 日本薬学会中国四国支部支部幹事
  • 2012/04 - 2019/09 International Pharmacy Federation Board of Pharmaceutical Sciences, Special Interest Group on Drug Design and Discovery
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Awards (2)：
  • 2009 - 日本薬学会関東支部奨励賞
  • 2004 - 有機合成化学協会研究企画賞
Association Membership(s) (5)：
The Japanese Association of Molecular Target Therapy of Cancer ,  Chemical Society of Japan ,  International Federation of Pharmacy ,  The Society of Synthetic Organic Chemistry, Japan ,  Pharmaceutical Society of Japan
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