Rchr
J-GLOBAL ID:201201090285537340
Update date: Nov. 24, 2024
ADACHI Noritaka
アダチ ノリタカ | ADACHI Noritaka
Affiliation and department:
Other affiliations (1):
Homepage URL (1):
http://dnar.sci.yokohama-cu.ac.jp/
Research field (4):
Cell biology
, Molecular biology
, Genetics
, Pharmaceuticals - health and biochemistry
Research keywords (15):
ヒトゲノム
, 老化
, がん
, 細胞周期
, 組換え
, DNA修復
, 分子生物学
, Aging
, Human Genome
, Cancer Chemotherapy
, Cancer Genetics
, Cell Cycle
, DNA Recombination
, DNA Repair
, Molecular Biology
Research theme for competitive and other funds (26):
- 2022 - 2024 条件的遺伝子発現系の理論的構築による新規DNA修復欠損がん診断・治療戦略の開発
- 2019 - 2023 生体環境からみたゲノム組換え修復に関する包括的理解
- 2018 - 2020 Efficient suppression of random DNA integration
- 2015 - 2018 Development of high-efficiency gene targeting technologies
- 2014 - 2016 Genes that enable high-efficiency gene disruption in human cells
- 2014 - 2016 Role of DNA-PKcs in neurogenesis
- 2012 - 2015 Development and applications of high-efficiency gene targeting in human cells
- 2012 - 2014 Analysis of human genes that enable high-efficiency gene targeting
- 2011 - 2013 ゲノム切断修復におけるクロマチン構造の役割
- 2011 - 2012 Epigenetic marking by histone variant H3.3 during myeloid cell differentiation
- 2009 - 2011 GeneticanalysisofDNAstrandbreakrepairinhumancelIs
- 2008 - 2009 ヒト遺伝子ノックアウトシステムの効率化と疾患遺伝子機能解析への応用
- 2008 - 2009 ヒト染色体DNA切断とその修復機構
- 2006 - 2007 ヒトDNA鎖切断修復の逆遺伝学的解析と医療への応用
- 2006 - 2007 ヒト染色体DNA切断とその修復機構
- 2006 - 2007 Genetic studies on the interaction between base excision repair and recombinational repair using human gene knockout cells
- 2006 - 2007 Analysis of DNA strand break repair using human knockout cells
- 2004 - 2005 動物細胞のDNA鎖切断修復と非相同組換えに関する逆遺伝学的解析
- 2004 - 2004 ヒトプレB細胞よりBLM破壊株の作製とその非相同組換え能の解析
- 2004 - 2004 ヒト遺伝子の系統的な機能解析に向けた高効率ジーンターゲティング系の開発
- 2004 - 2004 トポイソメラーゼ阻害剤によるゲノム損傷の修復におけるDNA鎖切断修復機構の役割
- 2003 - 2004 Studies of base excision repair in cell mutants deficient. in either DNA polymerase, or flap endonuclease-1 or both, generated from chicken DT40 cells.
- 2003 - 2003 ヒトプレB細胞よりBLM破壊株の作製とそ非相同的末端連結能の解析
- 2002 - 2003 DT40細胞を用いた非相同組換え機構の遺伝的解析
- 2000 - 2001 ニワトリDT40細胞を用いた非相同組換え機構の遺伝的解析
- 1998 - 1999 DNAトポイソメラーゼIIαの生理的機能と発現制御機構
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Papers (103):
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Yuduki Someya, Shinta Saito, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa. Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks. Biochemical and Biophysical Research Communications. 2024. 739. 150977-150977
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Shinta Saito, Noritaka Adachi. Characterization and regulation of cell cycle-independent noncanonical gene targeting. Nature Communications. 2024. 15. 1. 5044-5044
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Tadaaki Nakajima, Akihiro Imai, Chihiro Ishii, Kota Tsuruyama, Risa Yamanaka, Yasuhiro Tomooka, Shinta Saito, Noritaka Adachi, Satomi Kohno, Tomomi Sato. SMAD2/3 signaling regulates initiation of mouse Wolffian ducts and proximal differentiation in Müllerian ducts. FEBS Open Bio. 2023
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Aya Kurosawa, Shinta Saito, Mikiko Sakurai, Mizuki Shinozuka, Yuduki Someya, Noritaka Adachi. Arsenic affects homologous recombination and single-strand annealing but not end-joining pathways during DNA double-strand break repair. The FEBS Journal. 2023
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Yuduki Someya, Sakine Kobayashi, Kazuya Toriumi, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa. A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style. Genes. 2023. 14. 2
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MISC (52):
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斎藤 慎太, 足立 典隆. 【分子標的薬を極める-基礎から臨床まで-】分子標的薬の基礎 相同組換え修復. 産科と婦人科. 2020. 87. 10. 1138-1144
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黒沢 綾, 高橋 昭久, 武田 茂樹, 柴田 淳史, 足立 典隆. 高LET線ならびに放射線類似薬により誘発されるDNA二本鎖切断の修復における修復経路の重要度の解析(Requirement of DNA double-strand break repair pathways for repairing high LET radiation- and radiomimetic agents-induced DNA damage). 日本放射線影響学会大会講演要旨集. 2020. 63回. 75-75
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足立 典隆. 研究者の最新動向 ランダム挿入反応の分子機構と完全阻害. Precision Medicine. 2020. 3. 6. 590-593
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坂本裕太, 斎藤慎太, 足立典隆. Functional analysis of human WHSC1 in DNA double-strand break repair. 日本環境変異原学会大会プログラム・要旨集. 2020. 49th (CD-ROM)
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斎藤慎太, 足立典隆. DNA polymerase θ is essential for alternative end-joining. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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Patents (3):
Books (2):
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Complete suppression of random integration in human cells
2019
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進化するゲノム編集技術
NTS 2015
Education (2):
- The University of Tokyo Graduate School of Pharmaceutical Sciences
- The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1):
Work history (2):
- 南カリフォルニア大学医学部
- Yokohama City University
Association Membership(s) (3):
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