Art

J-GLOBAL ID：201202201617375853   Reference number：12A0302298

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

アロステリック・インバースアゴニスト活性を持つ抗体によるGタンパク質共役型受容体の不活性化

Author (40)： HINO Tomoya (JST-ERATO, Kyoto, JPN) ,  ARAKAWA Takatoshi (JST-ERATO, Kyoto, JPN) ,  YURUGI-KOBAYASHI Takami (JST-ERATO, Kyoto, JPN) ,  IKEDA-SUNO Chiyo (JST-ERATO, Kyoto, JPN) ,  WEYAND Simone (JST-ERATO, Kyoto, JPN) ,  SHIMAMURA Tatsuro (JST-ERATO, Kyoto, JPN) ,  NOMURA Norimichi (JST-ERATO, Kyoto, JPN) ,  CAMERON Alexander D. (JST-ERATO, Kyoto, JPN) ,  KOBAYASHI Takuya (JST-ERATO, Kyoto, JPN) ,  IWATA So (JST-ERATO, Kyoto, JPN) ,  MURATA Takeshi (JST-ERATO, Kyoto, JPN) ,  HINO Tomoya (Kyoto Univ., Kyoto, JPN) ,  ARAKAWA Takatoshi (Kyoto Univ., Kyoto, JPN) ,  YURUGI-KOBAYASHI Takami (Kyoto Univ., Kyoto, JPN) ,  IKEDA-SUNO Chiyo (Kyoto Univ., Kyoto, JPN) ,  SHIMAMURA Tatsuro (Kyoto Univ., Kyoto, JPN) ,  NOMURA Norimichi (Kyoto Univ., Kyoto, JPN) ,  KOBAYASHI Takuya (Kyoto Univ., Kyoto, JPN) ,  IWATA So (Kyoto Univ., Kyoto, JPN) ,  MURATA Takeshi (Kyoto Univ., Kyoto, JPN) ,  IWANARI Hiroko (Univ. Tokyo, Tokyo, JPN) ,  NAKADA-NAKURA Yoshiko (Univ. Tokyo, Tokyo, JPN) ,  KUSANO-ARAI Osamu (Univ. Tokyo, Tokyo, JPN) ,  HAMAKUBO Takao (Univ. Tokyo, Tokyo, JPN) ,  NAKADA-NAKURA Yoshiko (Perseus Proteomics Inc, Tokyo, JPN) ,  KUSANO-ARAI Osamu (Inst. of Immunology Co. Ltd, Tokyo, JPN) ,  WEYAND Simone (Imperial Coll. London, London, GBR) ,  CAMERON Alexander D. (Imperial Coll. London, London, GBR) ,  IWATA So (Imperial Coll. London, London, GBR) ,  WEYAND Simone (Harwell Sci. and Innovation Campus, Didcot, GBR) ,  CAMERON Alexander D. (Harwell Sci. and Innovation Campus, Didcot, GBR) ,  IWATA So (Harwell Sci. and Innovation Campus, Didcot, GBR) ,  WEYAND Simone (Rutherford Appleton Lab., Didcot, GBR) ,  CAMERON Alexander D. (Rutherford Appleton Lab., Didcot, GBR) ,  IWATA So (Rutherford Appleton Lab., Didcot, GBR) ,  KOBAYASHI Takuya (JST-CREST) ,  KOBAYASHI Takuya (Kyoto Univ. Fac. of Medicine, Kyoto, JPN) ,  IWATA So (RIKEN, Yokohama, JPN) ,  MURATA Takeshi (RIKEN, Yokohama, JPN) ,  MURATA Takeshi (Chiba Univ., Chiba, JPN)
Material： Nature (London)  (Nature (Lond))
Volume： 482  Issue： 7384  Page： 237-240  Publication year： Feb. 09, 2012 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： allosteric effect ,  drug ,  *A2 receptor ,  *monoclonal antibody ,  antigen-antibody complex ,  immunoglobulin fragment ,  steric conformation ,  membrane receptor ,  crystal structure ,  tertiary structure ,  X-ray diffraction
Semi thesaurus term： Fab fragment ,  G protein-coupled receptor ,  *Receptor, Adenosine A2A ,  inverse agonist

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Biochemistry of antigens,antibodies,complements  (ED04020L)

Terms in the title (4)： 活性 ,  抗体 ,  Gタンパク質共役型受容体 ,  不活性化