Art

J-GLOBAL ID：201202284959737580   Reference number：12A1102272

Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study

急性骨髄性白血病の高齢患者に対して固定スケジュールおよび反応に応じた個別化の寛解導入療法のランダム化比較と地固め療法中および後のウベニメクス使用:JALSG GML200研究

Author (18)： WAKITA Atsushi (Nagoya City West Medical Center, Nagoya, JPN) ,  OHTAKE Shigeki (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  TAKADA Satoru (Saiseikai Maebashi Hospital, Maebashi, JPN) ,  YAGASAKI Fumiharu (Saitama Medical Univ. International Medical Center, Hidaka, JPN) ,  KOMATSU Hirokazu (Nagoya City Univ., Nagoya, JPN) ,  MIYAZAKI Yasushi (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  KUBO Kohmei (Aomori Prefectural Central Hospital, Aomori, JPN) ,  KIMURA Yukihiko (Tokyo Medical Univ., Tokyo, JPN) ,  TAKESHITA Akihiro (Hamamatsu Univ. School of Medicine, Hamamatsu, JPN) ,  ADACHI Yoko (Kobe Central Hospital of Insurance, Kobe, JPN) ,  KIYOI Hitoshi (Nagoya Univ. Graduate School of Medicine, Nagoya, JPN) ,  YAMAGUCHI Takuhiro (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  YOSHIDA Minoru (Teikyo Univ. School of Medicine, Kawasaki, JPN) ,  OHNISHI Kazunori (Hamamatsu Univ. School of Medicine, Shizuoka, JPN) ,  MIYAWAKI Shuichi (Tokyo Metropolitan Ohtsuka Hospital, Tokyo, JPN) ,  NAOE Tomoki (Nagoya Univ. Graduate School of Medicine, Nagoya, JPN) ,  UEDA Ryuzo (Nagoya City Univ., Nagoya, JPN) ,  OHNO Ryuzo (Aichi Cancer Center, Nagoya, JPN)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 96  Issue： 1  Page： 84-93  Publication year： Jul. 2012 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *acute myeloid leukemia ,...
Semi thesaurus term： personalized medicine ,...

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JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Substance index (3)： Daunorubicin ,  Enocitabine ,  Bestatin

Reference (27)：

• HIDDEMANN, W. Management of acute myeloid leukemia in elderly patients. J Clin Oncol. 1999, 17, 3569-3576
• GRIMWADE, D. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML) : analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood. 2001, 98, 1312-1320
• KANTARJIAN, H. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome : predictive prognostic models for outcome. Cancer. 2006, 106, 1090-1098
• APPELBAUM, FR. Age and acute myeloid leukemia. Blood. 2006, 107, 3481-3485
• ESTEY, E. Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol. 2007, 25, 1908-1915

Terms in the title (10)： 急性骨髄性白血病 ,  高齢患者 ,  スケジュール ,  個別化 ,  寛解導入療法 ,  ランダム化 ,  地固め療法 ,  ウベニメクス ,  JALSG ,  研究