Art

J-GLOBAL ID：201202287370927256   Reference number：12A0097895

Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp

鼻ポリープ無しまたは小型鼻ポリープ有りの慢性鼻副鼻腔炎の患者でのS-カルボキシメチルシステイン(カルボシステイン)とクラリスロマイシンによる併用療法の効果

Author (12)： MAJIMA Yuichi (Ise Municipal General Hospital, 3038 Kusube-cho, Ise, Mie 516-0014, JPN) ,  KURONO Yuichi (Kagoshima Univ., 8-35-1 Sakuragaoka, Kagoshima 890-8520, JPN) ,  HIRAKAWA Katsuhiro (Hiroshima Univ., 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, JPN) ,  ICHIMURA Keiichi (Jichi Medical Univ. School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JPN) ,  HARUNA Shinichi (Dokkyo Medical Univ. School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, JPN) ,  SUZAKI Harumi (Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, JPN) ,  KAWAUCHI Hideyuki (Shimane Univ., 89-1 Enya-cho, Izumo, Shimane 693-8501, JPN) ,  TAKEUCHI Kazuhiko (Mie Univ., 2-174 Edobashi, Tsu, Mie 514-8507, JPN) ,  NAITO Kensei (Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, JPN) ,  KASE Yasuhiro (Saitama Medical Univ., 38 Morohongo Moroyama-machi, Iruma-gun, Saitama 350-0495, JPN) ,  HARADA Tamotsu (Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192 Japan) ,  MORIYAMA Hiroshi (The Jikei Univ. School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, JPN)
Material： Auris Nasus Larynx  (International Journal of ORL & HNS)
Volume： 39  Issue： 1  Page： 38-47  Publication year： Feb. 2012 
JST Material Number： W2247A  ISSN： 0385-8146  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： 粘液溶解薬 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=12A0097895&from=J-GLOBAL&jstjournalNo=W2247A") }}

JST classification (3)： Clinical application of drugs acting on sensory organs  (GW04070V) ,  Clinical application of antibiotics acting on pathogenic organisms  (GX05030N) ,  Drug therapy(=pharmacotherapy)for diseases of ear,nose,pharynx and larynx  (GQ05020H)

Substance index (2)： Carbocysteine ,  Clarithromycin

Reference (22)：

• Majima Y, Sakakura Y. The effects of a long-term and low dose administration of clarithromycin in chronic sinusitis. Oto-Rhino-Laryngology Tokyo 1997; 40 (Suppl 2): 126S-32S.
• Wallwork B, Coman W, Mackay-Sim A, Greiff L. Cervin A. A doubleblind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 2006; 116: 189-93.
• Majima Y. Clinical implications of the immunomodulatory effects of macrolides on sinusitis. Am J Med 2004; 117 (Suppl 9A): 20S-5S.
• Zheng JP, Kang J, Huang SG, Chen P. Yao WZ, Yang L, et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomized placebo-controlled study. Lancet 2008; 371: 2013-8.
• Repine JE, Bast A, Lankhorst I, Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 156: 341-57.

Terms in the title (7)： 鼻ポリープ ,  慢性鼻副鼻腔炎 ,  患者 ,  S-カルボキシメチルシステイン ,  カルボシステイン ,  クラリスロマイシン ,  併用療法