Art

J-GLOBAL ID：201202287370927256   Reference number：12A0097895

Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp

鼻ポリープ無しまたは小型鼻ポリープ有りの慢性鼻副鼻腔炎の患者でのS-カルボキシメチルシステイン(カルボシステイン)とクラリスロマイシンによる併用療法の効果

Author (12)： MAJIMA Yuichi (Ise Municipal General Hospital, 3038 Kusube-cho, Ise, Mie 516-0014, JPN) ,  KURONO Yuichi (Kagoshima Univ., 8-35-1 Sakuragaoka, Kagoshima 890-8520, JPN) ,  HIRAKAWA Katsuhiro (Hiroshima Univ., 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, JPN) ,  ICHIMURA Keiichi (Jichi Medical Univ. School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JPN) ,  HARUNA Shinichi (Dokkyo Medical Univ. School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, JPN) ,  SUZAKI Harumi (Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, JPN) ,  KAWAUCHI Hideyuki (Shimane Univ., 89-1 Enya-cho, Izumo, Shimane 693-8501, JPN) ,  TAKEUCHI Kazuhiko (Mie Univ., 2-174 Edobashi, Tsu, Mie 514-8507, JPN) ,  NAITO Kensei (Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, JPN) ,  KASE Yasuhiro (Saitama Medical Univ., 38 Morohongo Moroyama-machi, Iruma-gun, Saitama 350-0495, JPN) ,  HARADA Tamotsu (Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192 Japan) ,  MORIYAMA Hiroshi (The Jikei Univ. School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, JPN)
Material： Auris Nasus Larynx  (International Journal of ORL & HNS)
Volume： 39  Issue： 1  Page： 38-47  Publication year： Feb. 2012 
JST Material Number： W2247A  ISSN： 0385-8146  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： 粘液溶解薬 ,...

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JST classification (3)： Clinical application of drugs acting on sensory organs  (GW04070V) ,  Clinical application of antibiotics acting on pathogenic organisms  (GX05030N) ,  Drug therapy(=pharmacotherapy)for diseases of ear,nose,pharynx and larynx  (GQ05020H)

Substance index (2)： Carbocysteine ,  Clarithromycin

Reference (22)：

• Majima Y, Sakakura Y. The effects of a long-term and low dose administration of clarithromycin in chronic sinusitis. Oto-Rhino-Laryngology Tokyo 1997; 40 (Suppl 2): 126S-32S.
• Wallwork B, Coman W, Mackay-Sim A, Greiff L. Cervin A. A doubleblind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 2006; 116: 189-93.
• Majima Y. Clinical implications of the immunomodulatory effects of macrolides on sinusitis. Am J Med 2004; 117 (Suppl 9A): 20S-5S.
• Zheng JP, Kang J, Huang SG, Chen P. Yao WZ, Yang L, et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomized placebo-controlled study. Lancet 2008; 371: 2013-8.
• Repine JE, Bast A, Lankhorst I, Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 156: 341-57.

Terms in the title (7)： 鼻ポリープ ,  慢性鼻副鼻腔炎 ,  患者 ,  S-カルボキシメチルシステイン ,  カルボシステイン ,  クラリスロマイシン ,  併用療法