Rchr
J-GLOBAL ID：201301005156772022
Update date: Nov. 18, 2024
Hamamoto Hiroshi
ハマモト ヒロシ | Hamamoto Hiroshi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://infectiousdiseases-yamagata-u.jp
Research field (3)：
Bacteriology
, Pharmaceuticals - health and biochemistry
, Clinical pharmacy
Research keywords (7)：
Host-Microbe interaction
, Chemical Biology
, Antimicrobials
, 細菌感染
, サイトカイン
, 自然免疫
, シグナル伝達
Research theme for competitive and other funds (15)：
- 2023 - 2026 新規抗菌治療薬のメナキノン誘導を伴う殺菌メカニズムの解明
- 2022 - 2025 歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明
- 2022 - 2025 歯周病原細菌などのバクテロイディア綱細菌固有のリポタンパク質輸送機構の解明
- 2021 - 2024 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
- 2019 - 2022 Mechanism of action analysis of novel antibiotics in host factor contribution to therapeutic efficacy
- 2015 - 2020 Platform for the identification of novel therapeutically effective antimicrobial agents
- 2018 - 2020 新規抗生物質「ライソシン(カイコシン)」の開発
- 2016 - 2018 宿主因子によって活性促進される抗生物質のメカニズム解析
- 2016 - 2017 宿主因子によって活性化する環状リポペプチド系抗生物質のメカニズム解析
- 2014 - 2015 新規抗生物質カイコシンと、宿主由来活性促進因子との相互作用解析
- 2014 - 2015 Development of lead commands for new anti-infective agents
- 2012 - 2014 Establishment of screening system for antifungal drugs using silkworm fungus infection model
- 2012 - 2012 Establishment of a screening system for therapeutically effective antibiotics
- 2011 - 2011 Evaluation of pharmacokinetic using silkworm as an animal model
- 2009 - 2010 Activation mechanism and functional analysis of insect cytokine PP on innate immune response
Show all
Papers (134)：
-
Hiroshi Hamamoto. Silkworm model of bacterial infection facilitates the identification of lysocin E, a potent, ultra-rapid bactericidal antibiotic. The Journal of antibiotics. 2024. 77. 8. 477-485
-
Pablo Iturbe, Alvaro San Martín, Hiroshi Hamamoto, Marina Marcet-Houben, Toni Galbaldón, Cristina Solano, Iñigo Lasa. Noncontiguous operon atlas for the Staphylococcus aureus genome. microLife. 2024. 5. uqae007
-
Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023
-
Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. e202301225
-
Hiroshi Hamamoto, Atsushi Miyashita, Koushirou Kamura, Ryo Horie, Kazuhisa Sekimizu. Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret. Drug discoveries & therapeutics. 2022. 16. 6. 280-285
ｍore...
MISC (62)：
-
浜本洋, 石島早苗, PANTHEE Suresh, 関水和久. Cryptococcus neoformansの病原性因子の網羅的探索. 関東医真菌懇話会プログラム・抄録集. 2022. 41st
-
浜本洋, 石島早苗, 関水和久. Cryptococcus neoformansの病原性発揮機構の網羅的な理解. 日本医真菌学会雑誌. 2022. 63. Supplement 1
-
浜本 洋. 微生物と宿主の相互作用を利用する新しい作用機序の抗生物質-ライソシンEの治療効果の発揮機構の解明. ファルマシア. 2022. 58. 10. 959-963
-
浜本洋, PANTHEE Suresh, PAUDEL Atmika, 宮下惇嗣, 関水和久, 関水和久. A novel antibiotic Lysocin E exhibits high therapeutic efficacy through host-microbe interaction. 日本細菌学雑誌(Web). 2022. 77. 1
-
浜本, 洋. カイコを用いた医真菌の病原性の評価と抗真菌薬の開発-Evaluation of pathogenicity of medical mycology and development of antifungal drugs using silkworm model. Medical mycology research. 2021. 12. 1. 27-33
ｍore...
Patents (27)：
Professional career (1)：
Work history (6)：
Committee career (4)：
- 2023/01 - 現在 Journal of Antibiotics (Tokyo), Editorial Board Member
- 2018/04 - 現在 ナショナルバイオリソースプロジェクト「カイコ」 運営委員
- 2007/06 - 現在 Drug Discovery and Therapeutics誌, Associate Editor
- 2021/03 - 2024/03 日本医療開発機構 AMED課題評価委員
Awards (2)：
- 2024/08 - Japanese Society for Bacterilogoy Kobayashi Rokuzo Memorial Award Development of next-generation antimicrobial agents with unique mechanisms of action.
- 2023/11 - Sumiki-Umezawa Memorial Award
Return to Previous Page
