2022 - 2025 Pathobiological role of Ca2+/calmodulin-dependent PDE1 in HFpEF
2022 - 2025 Pathophysiology and Clinical Impact of Anemia in Patients with Advanced Heart Failure
2022 - 2025 Golgi apparatus-centered organelle network in cardiac remodeling
2022 - 2024 O結合グリコシル化制御に基づくサルコペニアの新規治療法開発
2021 - 2024 マイオカインによる老化進展制御機構の解明
2018 - 2023 Role of alpha-defensins derived from the small intestine and gut microbiota in heart failure
2018 - 2021 Study on the mechanism of regulation of mitochondrial function by brain-derived neurotrophic factor
2017 - 2020 The role of protein lysine-acetlation in congenital heart disease
2015 - 2018 Role of epicardial adipose tissue mitochondria in cardiovascular disease
2015 - 2018 Effects of skeletal muscle ischemic preconditioning for fatigability and damage protection
2015 - 2018 Regulatory mechanism of mitochondrial iron contents by mitoMEET in cardiac remodeling
2015 - 2017 Regulatory mechanism of mitochondrial morphology by Nox4 and treatment for heart failure
2015 - 2017 The role of Helicobacter Pylori in heart failure and effect of eradiation of Helicobacter Pylori
2014 - 2017 Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients
2014 - 2017 The role of mitoNEET on the regulation of mitochondrial function in skeletal muscle failure
2012 - 2016 Comprehensive risk assessment by using myocardial flow reserve in patients with diastolic dysfunction
2013 - 2015 Regulating mechanism of mitochondrial function by Nox4 in cardiac remodeling
2012 - 2015 Nutritional status and clinical outcomes in patients with heart failure: Clinical nutritional epidemiology
2012 - 2015 Role of natural killer T cells in myocardial remodeling and its therapeutic implication.
2011 - 2015 Role of natural killer T cells in chronic inflammation of atherogenesis
2011 - 2015 Adaptive servo-ventilation improves cardiac sympathetic nerve activity in patients with heart failure: Evaluation by cardiac 11C-Hydroxyephedrine positron emission tomography
2013 - 2014 Development of novel preventive strategy for post-infarct cardiac rupture via the regulation of inflammatory process by the activation of natural killer T cells
2011 - 2013 Resistance training with blood flow restriction: from basic physiological study to creative clinical application
2012 - 2012 Development of novel therapeutic strategy for atherosclerotic vascular diseases via the activation of natural killer T cells
2008 - 2012 Regulation of mitochondrial ROS signaling in the cardiovascular stress response
2009 - 2011 Study on the molecular mechanisms and treatment for mitochondrial regulation in cardiac remodeling
2008 - 2010 Study on the molecular mechanisms and treatment for the impaired exercise capacity in metabolic syndrome
2006 - 2007 酸化ストレス制御による心不全における運動能力改善を目指した新規治療法の開発
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Papers (210):
Takeshi Sota, Yoshiharu Kinugasa, Natsuko Nakayama, Kensuke Nakamura, Masayuki Hirai, Masahiko Kato, Taisuke Ono, Masashige Takahashi, Hisashi Matsuo, Ryuichi Matsukawa, et al. Associations of serum branched-chain amino acid and marine omega-3 fatty acid levels with exercise intolerance in heart failure patients. Clinical Nutrition Open Science. 2024. 57. 241-252
Toru Hashimoto, Kei Ikuta, Shoei Yamamoto, Tomoaki Yoshitake, Tomoyasu Suenaga, Shunsuke Nakashima, Takashi Kai, Kayo Misumi, Takeo Fujino, Keisuke Shinohara, et al. Right Ventricular to Pulmonary Artery Uncoupling Is Associated With Impaired Exercise Capacity in Patients With Transthyretin Cardiac Amyloidosis. Circulation journal : official journal of the Japanese Circulation Society. 2024
Takashi Yokota, Shintaro Kinugawa, Arata Fukushima, Takahiro Okumura, Toyoaki Murohara, Hiroyuki Tsutsui. Efficacy and safety of the urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia: results from the LEAF-CHF study. Heart and Vessels. 2024
Shota Ikeda, Keisuke Shinohara, Soichiro Kashihara, Sho Matsumoto, Daisuke Yoshida, Ryosuke Nakashima, Yoshiyasu Ono, Shouji Matsushima, Hiroyuki Tsutsui, Shintaro Kinugawa. Esaxerenone: blood pressure reduction and cardiorenal protection without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2024
Shota Ikeda, Keisuke Shinohara, Koshiro Tagawa, Takeshi Tohyama, Junji Kishimoto, Masaya Kazurayama, Shinji Tanaka, Masamitsu Yamaizumi, Hirokazu Nagayoshi, Kensuke Toyama, et al. Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population. Scientific Reports. 2024. 14. 1
国際心臓研究会日本部会
, JAPANESE HEART FAILURE SOCIETY
, JAPANESE COLLEGE OF CARDIOLOGY
, 日本心臓リハビリテーション学会
, THE JAPANESE CIRCULATION SOCIETY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE