Art

J-GLOBAL ID：202002223418066000   Reference number：20A0061701

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

エパグリフロジンは心不全のマウスモデルにおける骨格筋脂肪酸酸化の活性化を介して運動持久力を低下させる【JST・京大機械翻訳】

Author (17)： Nambu Hideo (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Takada Shingo (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Takada Shingo (Department of Lifelong Sport, School of Sports Education, Hokusho University, Ebetsu, Japan) ,  Fukushima Arata (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Matsumoto Junichi (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Kakutani Naoya (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Kakutani Naoya (Research Fellow of the Japan Society for the Promotion of Science, Japan) ,  Maekawa Satoshi (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Shirakawa Ryosuke (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Nakano Ippei (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Furihata Takaaki (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Katayama Takashi (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Yamanashi Katsuma (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Obata Yoshikuni (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Saito Akimichi (Institute of Preventive Medical Sciences, Health Sciences University of Hokkaido, Sapporo, Japan) ,  Yokota Takashi (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Kinugawa Shintaro (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 866  Page： Null  Publication year： 2020 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Decreased exercise capacity, w...

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Thesaurus term： ketone body ,  food ,  durability ,  oxidative phosphorylation ,  myocardial infarction ,  muscle force ,  *fatty acid ,  *skeletal muscle ,  mitochondria ,  substrate(biochemistry) ,  motor capacity ,  type 2 diabetes mellitus ,  *cardiac insufficiency ,  hexose ,  aldose
Semi thesaurus term： *脂肪酸酸化 , 【Automatic Indexing@JST】

Author keywords (6)： Myocardial infarction ,  Exercise intolerance ,  Mitochondria ,  SGLT2 inhibitor ,  Ketone body ,  Muscle strength

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (1)： Glucose

Terms in the title (7)： 心不全 ,  マウスモデル ,  骨格筋 ,  脂肪酸酸化 ,  活性化 ,  運動 ,  持久力