Rchr
J-GLOBAL ID：201301036815927414   Update date: Jan. 30, 2024

Bunsyo Shiotani

シオタニ ブンショウ | Bunsyo Shiotani
Affiliation and department：
National Cancer Center,Research Institute

About National Cancer Center,Research Institute


Job title： Laboratory Head
Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/10627665.ja.html
Research field  (1)： Cell biology
Research keywords  (5)： hallmark of cancer ,  Oncology ,  ATR ,  genome instability ,  DNA replication stress
Research theme for competitive and other funds  (9)：
  • 2022 - 2026 Cellular survival strategy through ATR-dependent DNA replication stress tolerance
  • 2022 - 2025 DNA複製ストレス応答機構に着目したBRCA2-VUS変異陽性細胞株の特徴の検証
  • 2020 - 2023 複製ストレス応答における癌抑制因子の新機能と染色体不安定化の抑制機構の解明
  • 2019 - 2022 Elucidation of the mechanism underlying DNA replication stress response regulating genomic instability
  • 2018 - 2022 Elucidation of the mechanism underlying tumor initiation via DNA replication stress regulated by ATR
Show all
Papers (30)：
  • Taichi Igarashi, Marianne Mazevet, Takaaki Yasuhara, Kimiyoshi Yano, Akifumi Mochizuki, Makoto Nishino, Tatsuya Yoshida, Yukihiro Yoshida, Nobuhiko Takamatsu, Akihide Yoshimi, et al. An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress. Nature Communications. 2023. 14. 1
  • Chiharu Uchida, Hiroyuki Niida, Satoshi Sakai, Kenta Iijima, Kyoko Kitagawa, Tatsuya Ohhata, Bunsyo Shiotani, Masatoshi Kitagawa. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2023. 1870. 6. 119484-119484
  • Kiminori Kurashima, Hideto Kashiwagi, Iwao Shimomura, Ayako Suzuki, Fumitaka Takeshita, Marianne Mazevet, Masahiko Harata, Takayuki Yamashita, Yusuke Yamamoto, Takashi Kohno, et al. SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma. NAR Cancer. 2020. 2. 2
  • Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, Shibata A, Miyagawa K. Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair. Cell. 2018. 175. 2. 558-570.e11
  • Naofumi Asano, Akihiko Yoshida, Sachiyo Mitani, Eisuke Kobayashi, Bunsyo Shiotani, Motokiyo Komiyama, Hiroyuki Fujimoto, Hirokazu Chuman, Hideo Morioka, Morio Matsumoto, et al. Frequent amplification of receptor tyrosine kinase genes in well-differentiated/dedifferentiated liposarcoma. ONCOTARGET. 2017. 8. 8. 12941-12952
ｍore...
Education (3)：
  • 1999 - 2002 Kobe University Graduate School of Life Science
  • 1997 - 1999 kobe University Graduate School of Life Science
  • 1994 - 1997 Kobe University Faculty of Agriculture Biofunctional chemistry
Professional career (1)：
  • 博士(学術) (神戸大学)
Work history (5)：
  • 2021/10 - 現在 National Cancer Center Research Institute Laboratory of Genome Stress Signaling Laboratory Head
  • 2014/10 - 2021/09 National Cancer Center Research Institute Division of Cellular Signaling Senior Staff Scientist
  • 2011/12 - 2014/09 Hiroshima University
  • 2005/07 - 2011/10 Massachusetts General Hospital / Harvard Medical School Cancer Center Research Fellow
  • 2002/04 - 2005/06 National Cancer Center Research Institute Research Resident
Awards (2)：
  • 2008/04 - Ataxia-telangiectasia Workshop Young Investigator Award
  • 2006/04 - Harvard Medical School Tosteson Postdoctoral Fellowship
Association Membership(s) (4)：
THE JAPANESE RADIATION RESEARCH SOCIETY ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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