Research keywords (4)：
alpha-synuclein
, Multiple system atrophy
, Dementia with Lewy bodies
, Parkinson's disease
Research theme for competitive and other funds (4)：
2017 - 2019 Development of novel mice models replicating Parkinson's disease pathology from its initial lesion
2015 - 2018 Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations
2015 - 2017 Genetic research on Parkinson's disease using medaka fish
2014 - 2016 Analyzing the pathogenesis of neurodegenerative diseases using medaka with multigene mutations.
Papers (56)：
Norihito Uemura, Nicholas P Marotta, Jahan Ara, Emily S Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Q Trojanowski, Virginia M-Y Lee. α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice. Nature communications. 2023. 14. 1. 6892-6892
上村 紀仁, Marotta Nicholas, Ara Jahan, Meymand Emily, Zhang Bin, 亀田 浩司, 小池 正人, Luk Kelvin, Trojanowski John, Lee Virginia. Distinct biological activity of Lewy body α-Synuclein strain in mice(タイトル和訳中). パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2023. 17回. 75-75
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, et al. Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 23. e2214652120
Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto, Tomoyuki Taguchi, Masanori Sawamura, Etsuro Nakanishi, Masashi Ikuno, Shuichi Matsuzawa, Hodaka Yamakado, Ryosuke Takahashi. Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission. Movement disorders : official journal of the Movement Disorder Society. 2023
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin Luk, John Trojanowski, Virginia Lee. Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square. 2023
