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J-GLOBAL ID：201802271252858190   Reference number：18A0493813

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

多系統萎縮症における介在物を誘発する潜在的オリゴデンドロサイト前駆細胞における病理学的内因性α-シヌクレイン蓄積【Powered by NICT】

Author (24)： Kaji Seiji (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Maki Takakuni (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Kinoshita Hisanori (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Uemura Norihito (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Ayaki Takashi (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Kawamoto Yasuhiro (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan) ,  Kawamoto Yasuhiro (Department of Neurology, Rakusai Shimizu Hospital, Nishikyo-ku, 610-1106 Kyoto, Japan) ,  Furuta Takahiro (Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Urushitani Makoto (Department of Neurology, Shiga University of Medical Science, Otsu, 520-2192 Shiga, Japan) ,  Hasegawa Masato (Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506 Tokyo, Japan) ,  Kinoshita Yusuke (Department of Developmental Neurobiology, KAN Research Institute, Inc., Kobe, 650-0047 Hyogo, Japan) ,  Ono Yuichi (Department of Developmental Neurobiology, KAN Research Institute, Inc., Kobe, 650-0047 Hyogo, Japan) ,  Mao Xiaobo (Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Quach Tran H. (Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Iwai Kazuhiro (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Dawson Valina L. (Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Valina L. (Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Valina L. (Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Valina L. (Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA) ,  Dawson Ted M. (Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Department of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA) ,  Takahashi Ryosuke (Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8397 Kyoto, Japan)
Material： Stem Cell Reports
Volume： 10  Issue： 2  Page： 356-365  Publication year： 2018 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Glial cytoplasmic inclusions (...

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Thesaurus term： human(primates) ,  *oligodendroglia ,  protein ,  neuron ,  cytoplasm ,  cell culture ,  aggregate ,  proteolysis ,  *pathology ,  inclusion body
Semi thesaurus term： *シヌクレイン ,  ミエリン形成 ,  *内因性 ,  *オリゴデンドログリア前駆細胞 ,  *多系統萎縮症 , 【Automatic Indexing@JST】

Author keywords (10)： α-synuclein ,  oligodendrocytes ,  oligodendrocyte precursor cells ,  primary cell culture ,  multiple system atrophy ,  synucleinopathy ,  glial cytoplasmic inclusion ,  neurotrophic factor ,  misfolding ,  autophagy

JST classification (3)： Central nervous system  (EJ12030F) ,  Nervous system diseases  (GN03000O) ,  Cell physiology in general  (EF02010S)

Terms in the title (8)： 多系統萎縮症 ,  介在物 ,  誘発 ,  オリゴデンドロサイト前駆細胞 ,  病理学 ,  内因性 ,  α-シヌクレイン ,  蓄積