Rchr
J-GLOBAL ID：201301097974267556   Update date: Dec. 26, 2024

Okamoto Ken

オカモト ケン | Okamoto Ken
Affiliation and department：
The University of Tokyo Faculty of Medicine

About The University of Tokyo Faculty of Medicine


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/60267143.ja.html
Research field  (6)： Medical biochemistry ,  Pathobiochemistry ,  Functional biochemistry ,  Neuroscience - general ,  Biochemistry ,  Structural biochemistry
Research keywords  (33)： molybdenum enzymes ,  enzyme mechanism ,  structural biology ,  enzyme inhibitors ,  xanthine oxidase ,  xanthine oxidoreductase ,  キサンチン脱水素酵素 ,  キサンチン酸化酵素 ,  X線結晶構造解析 ,  xanthine dehydrogenase ,  スーパーオキシド ,  阻害剤 ,  抗痛風薬 ,  キサンチン酸化還元酵素 ,  トランスジェニックマウス ,  構造ベース創薬 ,  iron-sulfur center ,  分子病態学 ,  構造生物学 ,  鉄硫黄中心 ,  活性酸素 ,  X線結晶解析 ,  フラビン酵素 ,  非ヘム鉄 ,  金属タンパク質 ,  金属フラビン酵素 ,  フリーラジカル ,  鉄結合タンパク質 ,  NO合成酵素 ,  結晶構造 ,  EPR ,  flavoprotein ,  モリブデン酵素
Research theme for competitive and other funds  (18)：
  • 2015 - 2018 Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
  • 2014 - 2017 The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
  • 2012 - 2015 Systemic and long term analysys of O2- hyperproduction mice
  • 2011 - 2013 The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
  • 2008 - 2010 Phasogenesis study of XOR mutant knock-in mouse.
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Papers (60)：
  • Sibo Wei, Li Li, Peng Lu, Michio Suzuki, Suguru Okuda, Ken Okamoto, Hideaki Itoh, Koji Nagata. Identification of a novel subtilisin-derived peptide, SC-(1-31), with cytotoxic activity. Biochemical and Biophysical Research Communications. 2025. 742. 151101-151101
  • Jinyan Jiang, Suguru Okuda, Hideaki Itoh, Ken Okamoto, Hiromi Nakanishi, Michio Suzuki, Peng Lu, Koji Nagata. Structure-Guided Discovery of a Potent Inhibitor of the Ferric Citrate Binding Protein FecB in Vibrio Bacteria. Angewandte Chemie (International ed. in English). 2024. e202411688
  • Mai Sekine, Megumi Fujiwara, Ken Okamoto, Kimiyoshi Ichida, Koji Nagata, Russ Hille, Takeshi Nishino. Significance and Amplification Methods of the Purine Salvage Pathway in Human Brain Cells. Journal of Biological Chemistry. 2024
  • Changyu Zhang, Peng Lu, Sibo Wei, Chaoyue Hu, Mitsuko Miyoshi, Ken Okamoto, Hideaki Itoh, Suguru Okuda, Michio Suzuki, Hiroshi Kawakami, et al. Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli. The Protein Journal. 2024. 43. 2. 283-297
  • 小宅菜月, 石山竜成, 佐藤悠大, 関根舞, 市田公美, 岡本研, 西野武士. Rhodobacter capsulatusのキサンチン脱水素酵素における水酸化反応の性質. 日本痛風・尿酸核酸学会総会プログラム・抄録集. 2024. 57th
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MISC (187)：
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Patents (5)：
Professional career (1)：
  • 医学博士
Work history (2)：
  • 2018/04 - 現在 Graduate School of Agricultural and Life Sciences, The University of Tokyo Department of Applied Biological Chemistry Project Researcher
  • 2012 - Nippon Medical School Medical School
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