Research field (6)：
Medical biochemistry
, Pathobiochemistry
, Functional biochemistry
, Neuroscience - general
, Biochemistry
, Structural biochemistry
Research theme for competitive and other funds (18)：
2015 - 2018 Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
2014 - 2017 The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
2012 - 2015 Systemic and long term analysys of O2- hyperproduction mice
2011 - 2013 The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
2008 - 2010 Phasogenesis study of XOR mutant knock-in mouse.
2006 - 2008 Molecular basis of structure-based drug design
2004 - 2007 Determination of fine structure of the molybdo-enzyme and mechanism of hydroxylation and protein vibration.
2000 - 2004 金属が関与するセンサーとスイッチのケミカルバイオロジー
2001 - 2003 Structure and function complex flavo-proteins which produce free radicals
1997 - 2000 Structures and functions of metalloflavoenzymes which produce free radicals
1998 - 1999 The structure and function of a complex metalloflavoprotein
1998 - 1999 キサンチン酸化酵素における非ヘム鉄の機能に関する研究
1997 - 1997 小脳におけるパルス状一酸化窒素発生の分子機構
1996 - 1996 キサンチン酸化酵素における非ヘム鉄の機能に関する研究
1993 - 1995 Electron transport system on complex flavoprotein
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Papers (47)：
Peng Lu, Jinyan Jiang, Chang Liu, Suguru Okuda, Hideaki Itoh, Ken Okamoto, Michio Suzuki, Koji Nagata. Molecular Mechanism of Fe3+ Binding Inhibition to Vibrio metschnikovii Ferric Ion-Binding Protein, FbpA, by Rosmarinic Acid and its Hydrolysate, Danshensu. Protein Science. 2023
Mai Sekine, Ken Okamoto, Emil F. Pai, Koji Nagata, Kimiyoshi Ichida, Russ Hille, Takeshi Nishino. Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase. Journal of Biological Chemistry. 2023
Peng Lu, Jiaqiao Zhou, Sibo Wei, Konosuke Takada, Hayato Masutani, Suguru Okuda, Ken Okamoto, Michio Suzuki, Tomoya Kitamura, Kentaro Masujin, et al. Comparative genomic and transcriptomic analyses of African swine fever virus strains. Computational and Structural Biotechnology Journal. 2023. 21. 4322-4335
Teruo Kusano, Tomoko Nishino, Ken Okamoto, Russ Hille, Takeshi Nishino. The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells. Redox Biology. 2023
Daisuke Miyamoto, Nana Sato, Koji Nagata, Yukinao Sakai, Hitoshi Sugihara, Yuki Ohashi, Blanka Stiburkova, Ivan Sebesta, Kimiyoshi Ichida, Ken Okamoto. Analysis of Purine Metabolism to Elucidate the Pathogenesis of Acute Kidney Injury in Renal Hypouricemia. Biomedicines. 2022. 10. 7. 1584-1584
小澤友弥, ZHANG Mimin, LU Peng, 岡本研, 伊藤英晃, 鈴木道生, 花田耕介, 柘植尚志, 中曽根光, 米倉円佳, et al. Identification and mechanism analysis of a plant peptide that inhibits the growth of Porphyromonas gingivalis. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
