Research field (6):
Medical biochemistry
, Pathobiochemistry
, Functional biochemistry
, Neuroscience - general
, Biochemistry
, Structural biochemistry
Research theme for competitive and other funds (18):
2015 - 2018 Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
2014 - 2017 The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
2012 - 2015 Systemic and long term analysys of O2- hyperproduction mice
2011 - 2013 The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
2008 - 2010 Phasogenesis study of XOR mutant knock-in mouse.
2006 - 2008 Molecular basis of structure-based drug design
2004 - 2007 Determination of fine structure of the molybdo-enzyme and mechanism of hydroxylation and protein vibration.
2000 - 2004 金属が関与するセンサーとスイッチのケミカルバイオロジー
2001 - 2003 Structure and function complex flavo-proteins which produce free radicals
1997 - 2000 Structures and functions of metalloflavoenzymes which produce free radicals
1998 - 1999 The structure and function of a complex metalloflavoprotein
1998 - 1999 キサンチン酸化酵素における非ヘム鉄の機能に関する研究
1997 - 1997 小脳におけるパルス状一酸化窒素発生の分子機構
1996 - 1996 キサンチン酸化酵素における非ヘム鉄の機能に関する研究
1993 - 1995 Electron transport system on complex flavoprotein
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Papers (60):
Sibo Wei, Li Li, Peng Lu, Michio Suzuki, Suguru Okuda, Ken Okamoto, Hideaki Itoh, Koji Nagata. Identification of a novel subtilisin-derived peptide, SC-(1-31), with cytotoxic activity. Biochemical and Biophysical Research Communications. 2025. 742. 151101-151101
Jinyan Jiang, Suguru Okuda, Hideaki Itoh, Ken Okamoto, Hiromi Nakanishi, Michio Suzuki, Peng Lu, Koji Nagata. Structure-Guided Discovery of a Potent Inhibitor of the Ferric Citrate Binding Protein FecB in Vibrio Bacteria. Angewandte Chemie (International ed. in English). 2024. e202411688
Mai Sekine, Megumi Fujiwara, Ken Okamoto, Kimiyoshi Ichida, Koji Nagata, Russ Hille, Takeshi Nishino. Significance and Amplification Methods of the Purine Salvage Pathway in Human Brain Cells. Journal of Biological Chemistry. 2024
Changyu Zhang, Peng Lu, Sibo Wei, Chaoyue Hu, Mitsuko Miyoshi, Ken Okamoto, Hideaki Itoh, Suguru Okuda, Michio Suzuki, Hiroshi Kawakami, et al. Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli. The Protein Journal. 2024. 43. 2. 283-297