Iwata Takeshi

イワタタケシ | Iwata Takeshi

Affiliation and department：
Job title：部長
Homepage URL (1)： https://iwatalab.org

Research field (1)： Ophthalmology

Research keywords (23)：遺伝性網膜疾患 , 加齢黄斑変性 , WDR36 , ARMS2 , HTRA1 , OPTN , MCAT , LRRTM4 , C21orf2 , CCT2 , RP1L1 , Knock-out mouse , Knock-in mouse , Chromatin , Enhancer , Non coding RNA , Whole genome analysis , Whole exome analysis , 緑内障 , オプチニュリン , トランスジェニックマウス , 網膜 , 網膜神経節細胞

Research theme for competitive and other funds (21)：

2017 - 2020 Construction of Cynomologus Monkey Model for Hereditary Retinal Diseases : Diseases Mechanisms and Therapeutic
2016 - 2019 Establishment of an intercontinental cohort database for ABCA4-associated retinal disorder, aiming for clinical trial of treatment
2015 - 2019 Function analysis for HTRA1 in AMD neovascularization.
2015 - 2018 Investigation of the onset mechanism of primary open-angle glaucoma -Genetic investigation of the mechanism of intraocular pressure elevation-
2015 - 2018 Induction of Muller glia-derived retinal regeneration by expressing regeneration promoting genes

2017 - 2018 Establishment of an intercontinental cohort database for ABCA4-associated retinal disorder in global eye genetic consortium, including 7 countries from Europe, America, and Asia(Fostering Joint International Research)

2014 - 2017 Primate model to study drusen formation and development of therapeutics

2015 - 2016 Development of disease monkey model for hereditary retinal disease by gene editing

2012 - 2016 The elucidation of glaucoma pathophysiology by the investigation of Rab8 and ERM family interaction in the ocular ciliary body

2014 - 2015 Development of cynomolgus monkey with hereditary retinal diseases

2013 - 2015 Investigation of clinical and molecular genetic characteristics of inherited macular diseases for treatment approach

2013 - 2014 Development and pathological characterization of genetically modified macaque monkey with eye disease.

2009 - 2011 Characterization of mouse models for glaucoma

2009 - 2011 T hestudyofinteractionbetweenRab8andERMfamily i ntheocularciliarybody

2008 - 2010 原発開放隅角緑内障の原因遺伝子(Myocilin)の機能解析

2007 - 2009 緑内障の発症機序の解明及び早期診断・治療法の開発

2006 - 2007 Functional analysis of primary open-angle glaucoma associated WDR36 gene.

2004 - 2005 Analysis of glaucoma-related protein interaction

2002 - 2003 Study of glaucoma associated genes and development of DNA diagnostic panel and therapeutic vector

2000 - 2001 Study of theretinal ganglion cell specific gene, optic atrophy, and gene threrapy

2000 - 2001 緑内障遺伝子ミオシリンの結合生体分子の解明とその分子間相互作用の解析

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Papers (220)：

Taiga Inooka, Takaaki Hayashi, Kazushige Tsunoda, Kazuki Kuniyoshi, Hiroyuki Kondo, Kei Mizobuchi, Akiko Suga, Takeshi Iwata, Kazutoshi Yoshitake, Mineo Kondo, et al. GENETIC ETIOLOGY AND CLINICAL FEATURES OF ACHROMATOPSIA IN JAPAN. Retina (Philadelphia, Pa.). 2024. 44. 10. 1836-1844
國吉一樹, 林孝彰, 須賀晶子, 溝渕圭, 吉武和敏, 立花都子, 堂本綾, 河合洋介, 大前陽輔, 徳永勝士, et al. 長鎖ゲノムシークエンスにより診断された青錐体一色覚の兄弟例. 日本眼科学会雑誌. 2024. 128. 臨増. 172-172
Akiko Suga, Kei Mizobuchi, Taiga Inooka, Kazutoshi Yoshitake, Naoko Minematsu, Kazushige Tsunoda, Kazuki Kuniyoshi, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, et al. A homozygous structural variant of RPGRIP1 is frequently associated with achromatopsia in Japanese patients with IRD. Genetics in Medicine Open. 2024. 101843-101843
Masato Akiyama, Gen Tamiya, Kohta Fujiwara, Yukihiro Shiga, Yu Yokoyama, Kazuki Hashimoto, Masataka Sato, Kota Sato, Akira Narita, Sawako Hashimoto, et al. Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals. Ophthalmology. 2024
Yukihiro Shiga, Kazuki Hashimoto, Kosuke Fujita, Shigeto Maekawa, Kota Sato, Shintaroh Kubo, Kazuhide Kawase, Kana Tokumo, Yoshiaki Kiuchi, Sotaro Mori, et al. Identification of OPTN p.(Asn51Thr): A novel pathogenic variant in primary open-angle glaucoma. Genetics in Medicine Open. 2024. 2. 100839-100839

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MISC (218)：

水元啓太郎, 加藤久美子, 松原央, 杉本昌彦, 杉田糾, 上野真治, 藤波芳, 角田和繁, 岩田岳, 近藤峰生. A case with Bardet-Biedle syndrome associated with ARL6 gene mutation. 日本眼科学会雑誌. 2021. 125
大石明生, 大石明生, 藤波芳, 馬渡剛, 直井信久, 上野真治, 國吉一樹, 林孝彰, 近藤寛之, 溝田淳, et al. Genetic and phenotypic landscape of PRPH2-associated retinal dystrophy in Japan. 日本眼科学会雑誌. 2021. 125
溝渕圭, 林孝彰, 林孝彰, 大石典子, 亀谷修平, 日笠幸一郎, 二見拓磨, 近藤寛之, 細野克博, 倉田健太郎, et al. Clinical and genetic findings of Japanese patients with RP1 gene. 日本眼科学会雑誌. 2021. 125
村上晶, 高丹, 藤巻拓郎, 舟木俊成, 山口昌大, 川村雄一, 藤木慶子, 岩田文乃, 平形寿彬, 平塚義宗, et al. Ophthalmologic Genetics-Molecular Genetics and Developments in Therapeutic Strategies for Intractable Eye Diseases-. 日本眼科学会雑誌. 2021. 125. 3
中条慎一郎, 大杉英子, 大杉英子, 田淵仁志, 田淵仁志, 永嶋竜之介, 上野真治, 藤波芳, 藤波芳, 角田和繁, et al. A case of autosomal recessive bestrophinopathy associated with angle-closure glaucoma. 眼科臨床紀要. 2020. 13. 3

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Work history (1)：

2011 - National Hospital Organization

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