Art

J-GLOBAL ID：201302203039781193   Reference number：13A1763658

Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide-Receptor Activation in Rats With Spinal Nerve Injury-Induced Neuropathy

脊髄神経損傷誘発神経障害を持つラットにおけるブプレノルフィンの抗痛覚過敏作用にはノシセプチン/オルファニンFQペプチド受容体活性化が関与する

Author (8)： TAKAHASHI Tomoko (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  OKUBO Kazumasa (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  KOJIMA Shota (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  NISHIKAWA Hiroyuki (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  TAKEMURA Motohide (Dep. of Oral Anatomy and Neurobiology, Osaka Univ. Graduate School of Dentistry, JPN) ,  TSUBOTA-MATSUNAMI Maho (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  SEKIGUCHI Fumiko (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN) ,  KAWABATA Atsufumi (Div. of Pharmacology & Pathophysiology, Kinki Univ. School of Pharmacy, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 122  Issue： 1  Page： 51-54 (J-STAGE)  Publication year： 2013 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： spinal nerve ,...
Semi thesaurus term： Hyperalgesia ,...

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JST classification (1)： Basic research of addictive analgesics and narcotics  (GW03080Z)

Substance index (2)： Nociceptin ,  Buprenorphine

Reference (14)：

• DAVIS, MP. Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain. J Support Oncol. 2012, 10, 209-219
• BLOMS-FUNKE, P. Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor. Peptides. 2000, 21, 1141-1146
• YAMAMOTO, T. Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. J Pharmacol Exp Ther. 2006, 318, 206-213
• CREMEANS, CM. Roles of mu-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates. J Pharmacol Exp Ther. 2012, 343, 72-81
• CHRISTOPH, T. Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain. Eur J Pharmacol. 2005, 507, 87-98

Terms in the title (11)： 脊髄神経 ,  損傷 ,  誘発 ,  神経障害 ,  ラット ,  ブプレノルフィン ,  痛覚過敏 ,  ノシセプチン ,  オルファニンFQ ,  ペプチド受容体 ,  活性化