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J-GLOBAL ID：201302207157297757   Reference number：13A1003064

NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers

Alzheimer病のマウスモデルにおける尿のNMRに基づくメタボロミクス 酸化ストレスバイオマーカーの同定

Author (11)： FUKUHARA Kiyoshi (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  OHNO Akiko (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  OTA Yosuke (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  SENOO Yuya (Div. of Medicinal Safety Sci., National Inst. of Health Sciences) ,  MAEKAWA Keiko (Div. of Medicinal Safety Sci., National Inst. of Health Sciences) ,  OKUDA Haruhiro (Div. of Drugs, National Inst. of Health Sciences) ,  KURIHARA Masaaki (Div. of Organic Chemistry, National Inst. of Health Sciences) ,  OKUNO Alato (Lab. of Radiation Safety, National Center for Geriatrics and Gerontology) ,  NIIDA Shumpei (Lab. of Genomics and Proteomics, National Center for Geriatrics and Gerontology) ,  SAITO Yoshiro (Div. of Medicinal Safety Sci., National Inst. of Health Sciences) ,  TAKIKAWA Osamu (Lab. of Radiation Safety, National Center for Geriatrics and Gerontology)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 52  Issue： 2  Page： 133-138 (J-STAGE)  Publication year： 2013 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Alzheimer Disease ,...

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JST classification (1)： Basic neurology  (GN01020W)

Reference (34)：

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• 3 Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms. Ann Neurol 2008; 64: 492窶錀498.
• 4 Bollard ME, Stanley EG, Lindon JC, Nicholson JK, Holmes E. NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed 2005; 18: 143窶錀162.
• 5 Serkova NJ, Spratlin JL, Eckhardt SG. NMR-based metabolomics: translational application and treatment of cancer. Curr Opin Mol Ther 2007; 9: 572窶錀585.

Terms in the title (8)： Alzheimer病 ,  マウスモデル ,  尿 ,  NMR ,  メタボロミクス ,  酸化ストレス ,  バイオマーカー ,  同定