Art

J-GLOBAL ID：201302217565810166   Reference number：13A1387825

Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

強力な抗HIV-1薬としての新規3-(3,5-ジメチルベンジル)ウラシルアナログの合成と評価

Author (10)： SAKAKIBARA Norikazu (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN) ,  HAMASAKI Takayuki (Div. of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences ...) ,  BABA Masanori (Div. of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences ...) ,  DEMIZU Yosuke (Div. of Organic Chemistry, National Inst. of Health Sciences, 1-18 Kamiyoga 1-Chome, Setagaya, Tokyo 158-8501, JPN) ,  KURIHARA Masaaki (Div. of Organic Chemistry, National Inst. of Health Sciences, 1-18 Kamiyoga 1-Chome, Setagaya, Tokyo 158-8501, JPN) ,  IRIE Kohji (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN) ,  IWAI Masatoshi (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN) ,  ASADA Eriko (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN) ,  KATO Yoshihisa (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN) ,  MARUYAMA Tokumi (Fac. of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri Univ., 1314-1 Shido, Sanuki City, Kagawa 769-2193, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 21  Issue： 18  Page： 5900-5906  Publication year： Sep. 15, 2013 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *anti-AIDS agent ,  HIV1 ,  *nitrogen heterocyclic compound ,  modeling ,  molecular structure ,  structure-activity relationship ,  selectivity ,  biological material analog ,  chemical synthesis ,  toxicity test ,  concentration(ratio) ,  reverse transcriptase ,  *enzyme inhibitor ,  docking ,  molecular recognition
Semi thesaurus term： median effective concentration ,  HIV-1 reverse transcriptase ,  *uracil derivative ,  *nonnucleoside reverse transcriptase inhibitor ,  molecular docking ,  molecular modeling

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Pyrimidines  (CF07103W)

Substance index (1)： 1-(4-Pyridylmethyl)-3-(3,5-dimethylbenzyl)-6-aminouracil

Terms in the title (4)： HIV-1 ,  ウラシル ,  アナログ ,  評価