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J-GLOBAL ID：201302217684333163   Reference number：13A0579239

Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs

関節リウマチ患者での腫瘍壊死因子阻害剤の臨床試験におけるKL-6血清濃度の上昇 生物学的DMARDの安全性についての日本リウマチ学会専門委員会からの報告

Author (20)： HARIGAI Masayoshi (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  HARIGAI Masayoshi (Tokyo Medical and Dental Univ., Dep. of Pharmacovigilance, Graduate School of Medical and Dental Sciences, 1-5-45 ...) ,  HARIGAI Masayoshi (Tokyo Medical and Dental Univ., Dep. of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences ...) ,  TAKAMURA Akito (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  TAKAMURA Akito (Tokyo Medical and Dental Univ., Dep. of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences ...) ,  ATSUMI Tatsuya (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  ATSUMI Tatsuya (Hokkaido Univ., Dep. of Internal Medicine II, Graduate School of Medicine, Sapporo, Hokkaido, JPN) ,  DOHI Makoto (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  DOHI Makoto (Graduate School of Medicine, Univ. of Tokyo, Dep. of Allergy and Rheumatology, Tokyo, JPN) ,  HIRATA Shintaro (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  HIRATA Shintaro (Univ. of Occupational and Environmental Health, Japan, The First Dep. of Internal Medicine, Kitakyushu, Fukuoka, JPN) ,  KAMEDA Hideto (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  KAMEDA Hideto (Keio Univ., Div. of Rheumatology and Clinical Immunology, Dep. of Internal Medicine, Fac. of Medicine, Tokyo, JPN) ,  NAGASAWA Hayato (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  NAGASAWA Hayato (Saitama Medical Univ., Dep. of Rheumatology/Clinical Immunology, Saitama Medical Center, Kawagoe, Saitama, JPN) ,  SETO Yohei (Japan Coll. of Rheumatology, The Ad Hoc Committee for the Safety of Biological DMARDs, 1-1-24 Toranomon, 105-0001 ...) ,  SETO Yohei (Tokyo Women’s Medical Univ., Inst. of Rheumatology, Tokyo, JPN) ,  KOIKE Takao (Sapporo Medical Center NTT EC, Chuo-ku, Sapporo, Hokkaido, JPN) ,  MIYASAKA Nobuyuki (Tokyo Medical and Dental Univ., Dep. of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences ...) ,  MIYASAKA Nobuyuki (Tokyo Medical and Dental Univ., Global Center of Excellence Program, International Res. Center for Molecular Sci. in ...)
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 23  Issue： 2  Page： 284-296  Publication year： Mar. 2013 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (2)： Clinical application of anti-inflammatory drugs  (GW15020E) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D)

Reference (22)：

• TAKEUCHI, T. Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis. 2008, 67, 189-194
• KOIKE, T. Postmarketing surveillance of the safety and effectiveness of etanercept in Japan. J Rheumatol. 2009, 36, 898-906
• KOMANO, Y. Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab : a retrospective review and case-control study of 21 patients. Arthritis Rheum. 2009, 61, 305-312
• HARIGAI, M. Pneumocystis pneumonia associated with infliximab in Japan. N Engl J Med. 2007, 357, 1874-1876
• STAHEL, RA. Third International Workshop on Lung Tumor and Differentiation Antigens : overview of the results of the central data analysis. Int J Cancer Suppl. 1994, 8, 6-26

Terms in the title (12)： 関節リウマチ ,  患者 ,  腫瘍壊死因子阻害剤 ,  臨床試験 ,  KL-6 ,  血清濃度 ,  生物学的DMARD ,  安全性 ,  日本 ,  リウマチ ,  学会 ,  報告