Art

J-GLOBAL ID：201302222761805638   Reference number：13A1586604

Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension

肺動脈高血圧症に対するトロンボキサンシンターゼ阻害活性を持つ新規長期作用プロスタサイクリン作動薬の経口投与

Author (11)： NAKAMURA Atsuhiro (Second Dep. of Internal Medicine, Nara Medical Univ.) ,  NAKAMURA Atsuhiro (Dep. of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Res. Inst.) ,  NAGAYA Noritoshi (Dep. of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Res. Inst.) ,  OBATA Hiroaki (Div. of Cardiology, Niigata Univ. Graduate School of Medical and Dental Sci.) ,  SAKAI Katsuya (Div. of Tumor Dynamics and Regulation, Molecular & Cellular Targeting Translational Oncology Center, Cancer Res. ...) ,  SAKAI Yoshiki (Ono Pharmaceutical Co Ltd, Res. Headquarters) ,  YOSHIKAWA Masanori (Second Dep. of Internal Medicine, Nara Medical Univ.) ,  HAMADA Kaoru (Second Dep. of Internal Medicine, Nara Medical Univ.) ,  HAMADA Kaoru (Dep. of Clinical Medicine, Fac. of Nursing, Nara Medical Univ.) ,  MATSUMOTO Kunio (Div. of Tumor Dynamics and Regulation, Molecular & Cellular Targeting Translational Oncology Center, Cancer Res. ...) ,  KIMURA Hiroshi (Second Dep. of Internal Medicine, Nara Medical Univ.)
Material： Circulation Journal  (Circ J)
Volume： 77  Issue： 8  Page： 2127-2133 (J-STAGE)  Publication year： 2013 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： thromboxane synthase inhibitor ,...

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JST classification (2)： Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (3)： Epoprostenol ,  ONO-1301 ,  cAMP

Reference (25)：

• RICH, S. Primary pulmonary hypertension : A national prospective study. Ann Intern Med. 1987, 107, 216-223
• FUKUMOTO, Y. Recent progress in the management of pulmonary hypertension. Circ J. 2011, 75, 1801-1810
• MCLAUGHLIN, VV. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med. 1998, 338, 273-277
• MCLAUGHLIN, VV. Pulmonary arterial hypertension. Circulation. 2006, 114, 1417-1431
• SITBON, O. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension : Prognostic factors and survival. J Am Coll Cardiol. 2002, 40, 780-788

Terms in the title (7)： 肺動脈高血圧症 ,  トロンボキサンシンターゼ ,  阻害活性 ,  長期 ,  プロスタサイクリン ,  作動薬 ,  経口投与