Art

J-GLOBAL ID：201302229844192837   Reference number：13A1928861

Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes

ヒト肝及び腸管ミクロソームにおけるチトクロムP450 2B6,2C8,2C19,2D6,3A活性に対する緑茶カテキンの影響

Author (11)： MISAKA Shingen (Dep. of Pharmacokinetics and Pharmacodynamics) ,  MISAKA Shingen (Dep. of Pharmacology, School of Medicine, Fukushima Medical Univ.) ,  KAWABE Keisuke (Dep. of Pharmacokinetics and Pharmacodynamics) ,  ONOUE Satomi (Dep. of Pharmacokinetics and Pharmacodynamics) ,  WERBA Jose Pablo (Centro Cardiologico Monzino IRCCS) ,  GIROLI Monica (Centro Cardiologico Monzino IRCCS) ,  TAMAKI Sekihiro (Dep. of Pharmacokinetics and Pharmacodynamics) ,  KAN Toshiyuki (Dep. of Synthetic Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, Univ. of Shizuoka) ,  KIMURA Junko (Dep. of Pharmacology, School of Medicine, Fukushima Medical Univ.) ,  WATANABE Hiroshi (Dep. of Clinical Pharmacology and Therapeutics, Hamamatsu Univ. School of Medicine) ,  YAMADA Shizuo (Dep. of Pharmacokinetics and Pharmacodynamics)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 3  Page： 244-249 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *green tea catechin ,...

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JST classification (1)： Clinical application of other drugs  (GW23020V)

Substance index (1)： (-)-Epigallocatechin gallate

Reference (35)：

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• 2) Custodio, J. M., Wu, C. Y. and Benet, L. Z.: Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv. Drug Deliv. Rev., 60: 717–733 (2008).
• 3) Kupferschmidt, H. H., Ha, H. R., Ziegler, W. H., Meier, P. J. and Krahenbuhl, S.: Interaction between grapefruit juice and midazolam in humans. Clin. Pharmacol. Ther., 58: 20–28 (1995).
• 4) Edwards, D. J., Bellevue, F. H., 3rd and Woster, P. M.: Identification of 6′,7′-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab. Dispos., 24: 1287–1290 (1996).
• 5) Graham, H. N.: Green tea composition, consumption, and polyphenol chemistry. Prev. Med., 21: 334–350 (1992).

Terms in the title (7)： ヒト ,  肝 ,  腸管 ,  ミクロソーム ,  チトクロムP450 ,  活性 ,  緑茶カテキン