Art

J-GLOBAL ID：201302236210961362   Reference number：13A0355875

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

ROSを生成するオキシダーゼNox1およびNox4は発癌性Rasに誘導される早期老化に寄与している

Author (9)： KODAMA Ryo (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  KATO Masayoshi (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  FURUTA Shuichi (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  UENO Shouta (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  ZHANG Yugen (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  MATSUNO Kuniharu (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  YABE-NISHIMURA Chihiro (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  TANAKA Eiji (Shinshu Univ. Graduate School of Medicine, Nagano, JPN) ,  KAMATA Tohru (Shinshu Univ. Graduate School of Medicine, Nagano, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 18  Issue： 1  Page： 32-41  Publication year： Jan. 2013 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： active oxygen ,...
Semi thesaurus term： MEK ,...

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JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Aging and death  (EJ16040S)

Reference (37)：

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• Chen, J.H., Stoeber, K., Kingsbury, S., Ozanne, S.E., Williams, G.H. & Hales, C.N. (2004) Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J. Biol. Chem. 279, 49439-49446.
• Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A.J., Barradas, M., Benguria, A., Zaballos, A., Flores, J.M., Barbacid, M., Beach, D. & Serrano, M. (2005) Tumour biology: senescence in premalignant tumours. Nature 436, 642.

Terms in the title (8)： ROS ,  オキシダーゼ ,  Nox1 ,  Nox4 ,  発癌性 ,  Ras ,  誘導 ,  早期老化