Art

J-GLOBAL ID：201302244655597256   Reference number：13A1145679

Synthesis and biological evaluation of new chlorin derivatives as potential photosensitizers for photodynamic therapy

光線力学療法用の潜在的な光増感剤としての新規クロリン誘導体の合成と生物学的評価

Author (7)： ASANO Ryuji (Fushimi Pharmaceutical Co., Ltd, 1676 Nakazu-cho, Marugame, Kagawa 763-8605, JPN) ,  NAGAMI Amon (Fac. of Life and Environmental Sciences, Prefectural Univ. of Hiroshima, 562 Nanatsuka-cho, Shobara, Hiroshima ...) ,  FUKUMOTO Yuki (Fac. of Life and Environmental Sciences, Prefectural Univ. of Hiroshima, 562 Nanatsuka-cho, Shobara, Hiroshima ...) ,  YAZAMA Futoshi (Fac. of Life and Environmental Sciences, Prefectural Univ. of Hiroshima, 562 Nanatsuka-cho, Shobara, Hiroshima ...) ,  ITO Hideyuki (Dep. of Pharmacognosy, Div. of Pharmaceutical Sciences, Okayama Univ. Graduate School of Medicine, Dentistry and ...) ,  SAKATA Isao (Porphyrin Lab, 1-2-35 Tsushimanishizaka, Kita-ku, Okayama 700-0086, JPN) ,  TAI Akihiro (Fac. of Life and Environmental Sciences, Prefectural Univ. of Hiroshima, 562 Nanatsuka-cho, Shobara, Hiroshima ...)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 21  Issue： 8  Page： 2298-2304  Publication year： Apr. 15, 2013 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,  *Photochemotherapy ,  *photosensitizer ,  bridged compound ,  macrocyclic compound ,  nitrogen heterocyclic compound ,  drug design ,  Structure-Activity Relationship ,  antitumor action ,  biodistribution ,  clearance ,  in vivo experiment ,  Mus musculus ,  *photodynamic therapy ,  chlorins ,  Myomorpha
Semi thesaurus term： chlorin derivatives

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (4)： [[2,7,13,17-Tetramethyl-18-vinyl-2-hydroxy-3-[2-(ethoxyimino)ethylidene]chlorin-8,12-diyl]bis[(3-oxotrimethylene)nitrilo]]tetra(acetic acid sodium) salt ,  [[2,7,13,17-Tetramethyl-18-vinyl-2-hydroxy-3-[2-(ethoxyimino)ethylidene]chlorin-8,12-diyl]bis[(3-oxotrimethylene)nitrilo]]tetra(acetic acid methyl) ester ,  2,7,13,17-Tetramethyl-18-vinyl-2-hydroxy-3-(2-hydroxyethylidene)chlorin-8,12-dipropionic acid disodium salt ,  2,7,13,17-Tetramethyl-18-vinyl-2-hydroxy-3-[2-(ethoxyimino)ethylidene]chlorin-8,12-dipropionic acid disodium salt

Terms in the title (4)： 光線力学療法 ,  光増感剤 ,  クロリン誘導体 ,  生物学的評価