Art

J-GLOBAL ID：201302245716217482   Reference number：13A1928862

Hepatocyte Nuclear Factor 6 Activates the Transcription of CYP3A4 in Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells

人工多能性幹細胞から分化した肝細胞様細胞において肝細胞核因子6はCYP3A4の転写を活性化する

Author (11)： SASAKI Takamitsu (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  TAKAHASHI Shogo (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  NUMATA Yoshihiro (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  NARITA Masayo (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  TANAKA Yutaka (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  KUMAGAI Takeshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  KONDO Yuki (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  MATSUNAGA Tamihide (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  OHMORI Shigeru (Dep. of Molecular Pharmacology, Shinshu Univ. Graduate School of Medicine) ,  OHMORI Shigeru (Dep. of Pharmacy, Shinshu Univ. Hospital) ,  NAGATA Kiyoshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 3  Page： 250-259 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： stem cell ,...
Semi thesaurus term： *CYP3A4 ,...

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JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Cell physiology in general  (EF02010S)

Reference (53)：

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• 4) Funakoshi, N., Duret, C., Pascussi, J. M., Blanc, P., Maurel, P., Daujat-Chavanieu, M. and Gerbal-Chaloin, S.: Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes. Stem Cell Rev., 7: 518–531 (2011).
• 5) Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S.: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131: 861–872 (2007).

Terms in the title (7)： 人工多能性幹細胞 ,  分化 ,  肝細胞様細胞 ,  肝細胞核因子6 ,  CYP3A4 ,  転写 ,  活性化