Art

J-GLOBAL ID：201302274629032000   Reference number：13A0602420

Driver Gene Mutation and Targeted Therapy of Lung Cancer

肺がんのドライバー遺伝子変異と分子標的治療

Author (1)： MITSUDOMI TETSUYA (近畿大 外科 呼吸器外科部門)
Material： 癌と化学療法  (Japanese Journal of Cancer and Chemotherapy)
Volume： 40  Issue： 3  Page： 285-290  Publication year： Mar. 15, 2013 
JST Material Number： Z0938A  ISSN： 0385-0684  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human ,...
Semi thesaurus term： genetic variation

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JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Clinical oncology in general  (GE03010Y)

Substance index (4)： Gefitinib ,  Erlotinib ,  Crizotinib ,  Everolimus

Reference (38)：

• 1) Fearon ER and Vogelstein B: A genetic model for color-ectal tumorigenesis. Cell 61 (5): 759-767, 1990.
• 2) Haber DA and Settleman J: Cancer: drivers and passen-gers. Nature 446 (7132) : 145-146, 2007.
• 3) Kris MG, Johnson BE, Kwiatkowski DJ, et al: Identifica-tion of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Can-cer Mutation Consortium (LCMC). 2011 ASCO Annual Meeting, J Clin Oncol 29 (Suppl) : abstr CRA7506, 2011.
• 4) McDermott U, Sharma SV, Dowell L, et al: Identification of genotype-correlated sensitivity to selective kinase in-hibitors by using high-throughput tumor cell line profil-ing. Proc Natl Acad Sci USA 104(50): 19936-19941, 2007.
• 5) Tyner JW, Walters DK, Willis SG, et al: RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood 111 (4): 2238-2245, 2008.

Terms in the title (3)： 肺がん ,  ドライバー遺伝子変異 ,  分子標的治療