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J-GLOBAL ID：201302293177843654   Reference number：13A0529115

p21 and Notch Signalings in the Persistently Altered Vagina Induced by Neonatal Diethylstilbestrol Exposure in Mice

マウスにおいて新生児期にジエチルスチルベステロールに暴露することで引き起こされる膣の持続的変化におけるp21およびNotchのシグナル

Author (10)： NAKAMURA Takeshi (Dep. of Basic Biology, Fac. of Life Sci., The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Inst. for ...) ,  NAKAMURA Takeshi (Dep. of Material and Biological Chemistry, Fac. of Sci., Yamagata Univ., Kojirakawa-machi, Yamagata 990-8560, JPN) ,  MIYAGAWA Shinichi (Dep. of Basic Biology, Fac. of Life Sci., The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Inst. for ...) ,  KATSU Yoshinao (Dep. of Basic Biology, Fac. of Life Sci., The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Inst. for ...) ,  KATSU Yoshinao (Graduate School of Life Sci. and Dep. of Biological Sciences, Hokkaido Univ., Sapporo 060-0810, JPN) ,  MIZUTANI Takeshi (Dep. of Basic Biology, Fac. of Life Sci., The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Inst. for ...) ,  SATO Tomomi (International Graduate School of Arts and Sciences, Yokohama City Univ., Yokohama 236-0027, JPN) ,  TAKEUCHI Takashi (Dep. of Veterinary Medicine, Fac. of Agriculture, Tottori Univ., Tottori 680-8553, JPN) ,  IGUCHI Taisen (Dep. of Basic Biology, Fac. of Life Sci., The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Inst. for ...) ,  OHTA Yasuhiko (Dep. of Veterinary Medicine, Fac. of Agriculture, Tottori Univ., Tottori 680-8553, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 74  Issue： 12  Page： 1589-1595 (J-STAGE)  Publication year： 2012 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *woman ,...
Semi thesaurus term： agonist ,...

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JST classification (1)： Basic gynecology and obstetrics  (GS01020L)

Substance index (1)： Diethylstilbestrol

Reference (56)：

• 1. Brugarolas, J., Chadrasekaran, C., Gordon, J., Beach, D., Jacks, T. and Hannon, G. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552–557.
• 2. Deng, C., Zhang, P., Harper, J. W., Elledge, S. J. and Leder, P. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675–684.
• 3. Devgan, V., Mammucari, C., Millar, S. E., Brisken, C. and Dotto, G. P. 2005. P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 19: 1485–1495.
• 4. Dulic, V., Kaufman, W. K., Wilson, S. J., Tlsty, T. D., Lees, E., Harper, J. W., Elledge, S. J. and Reed, S. I. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013–1023.
• 5. Dunn, T. B. and Green, A. W. 1963. Cysts of the epididymis, cancer of the cervix, granular cell myoblastoma, and other lesions after rogen injection in newborn mice. J. Natl. Cancer Inst. 31: 425–455.

Terms in the title (8)： マウス ,  新生児期 ,  ジエチルスチルベステロール ,  暴露 ,  膣 ,  p21 ,  Notch ,  シグナル