Art

J-GLOBAL ID：201302295330952711   Reference number：13A1888228

A CD4 mimic as an HIV entry inhibitor: Pharmacokinetics

HIV侵入阻害剤としてのCD4ミミック:薬物動態

Author (15)： HASHIMOTO Chie (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  NARUMI Tetsuo (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  OTSUKI Hiroyuki (Inst. for Virus Res., Kyoto Univ., Kyoto 606-8507, JPN) ,  HIROTA Yuki (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  ARAI Hiroshi (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  YOSHIMURA Kazuhisa (AIDS Res. Center, National Inst. of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, JPN) ,  YOSHIMURA Kazuhisa (Center for AIDS Res., Kumamoto Univ., Kumamoto 860-0811, JPN) ,  HARADA Shigeyoshi (AIDS Res. Center, National Inst. of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, JPN) ,  HARADA Shigeyoshi (Center for AIDS Res., Kumamoto Univ., Kumamoto 860-0811, JPN) ,  OHASHI Nami (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  NOMURA Wataru (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN) ,  MIURA Tomoyuki (Inst. for Virus Res., Kyoto Univ., Kyoto 606-8507, JPN) ,  IGARASHI Tatsuhiko (Inst. for Virus Res., Kyoto Univ., Kyoto 606-8507, JPN) ,  MATSUSHITA Shuzo (Center for AIDS Res., Kumamoto Univ., Kumamoto 860-0811, JPN) ,  TAMAMURA Hirokazu (Inst. of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., Chiyoda-ku, Tokyo 101-0062, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 21  Issue： 24  Page： 7884-7889  Publication year： Dec. 15, 2013 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： glycoprotein ,  viral infection ,  CD4 antigen ,  *HIV1 ,  viral protein ,  chemical compound ,  *rat ,  *Macaca mulatta ,  Macaca ,  intravenous administration ,  pharmacokinetics ,  biodistribution ,  drug distribution ,  plasma concentration ,  half-life ,  amide ,  nitrogen heterocyclic compound
Semi thesaurus term： *CD4 ,  gp120 ,  *HIV Envelope Protein gp120 ,  amides ,  virus entry ,  envelope glycoprotein ,  Macaque ,  *mimic ,  *lead compound ,  plasma concentration ,  Vd ,  *Pharmacokinetics

JST classification (9)： Nitrogen heterocycles in general  (CF07040G) ,  Aromatic monocyclic amine,imine,quaternary ammonium,immonium compounds  (CF05050D) ,  Basic research of antiviral drugs  (GW17040O) ,  Research methods  (GV01020U) ,  Interactions of drugs  (GV01070X) ,  Bioassay  (EA03060N) ,  Proteins and peptides in general  (EB03010N) ,  Research methods in biological sciences in general  (EA03010K) ,  Basic biopharmacy  (GY01021U)

Substance index (1)： YYA-021

Terms in the title (5)： HIV ,  侵入阻害剤 ,  CD4 ,  ミミック ,  薬物動態