SUGAI Manabu

スガイマナブ | SUGAI Manabu

Affiliation and department：
Job title： Professor

Research field (1)： Medical biochemistry

Research theme for competitive and other funds (31)：

2023 - 2026 腫瘍による免疫回避機構に対抗する宿主免疫細胞の機能解析
2018 - 2020 Intracellular labile heme: signaling function in cell differentiation and proliferation
2017 - 2020 Novel regulatory T cells induced and differentiated from CD4 T cells
2016 - 2019 Regulatory mechanisms of activated B cell fate which contribute diversity of immune response
2016 - 2019 Development of new immunotherapy through the regulation of mitochondrial function

2015 - 2018 Development of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples

2013 - 2018 Molecular mechanism of the regulation of antigen-specific immune reaction

2016 - 2018 ミトコンドリア機能制御による新規免疫療法の開発

2016 - 2018 免疫反応の多様性を演出する活性化B細胞分化制御機構ーミトコンドリアとB細胞分化ー

2015 - 2017 Basic research on technology development of tooth regeneration with regard to transcription factor Cebpb and Runx2

2015 - 2017 ミトコンドリア機能変化による細胞分化決定機構の解析

2014 - 2017 New approach to develop Lactosome-based therapy for allergic disease

2012 - 2017 Functional analysis of newly identified inducible regulatory T cells in immunological reaction and tolerance

2013 - 2016 Feasibility of Molecularly Targeted Therapy for Tooth Regeneration

2012 - 2014 Development of new therapies for tumor and autoimmunity using CD8aaT cells

2010 - 2012 Feasibility of gene therapy for tooth regeneration by stimulation of a third dentition

2009 - 2011 Analysis of the functional difference among various Id proteins

2008 - 2010 Changes in activity of the transcriptional regulator Id by toxic trace elements and redox signaling.

2006 - 2007 Mechanism s regulating the gene rearrangements in immune system

2005 - 2006 Molecular analysis of tooth regeneration

2005 - 2006 Molecular analysis of ANKH toward gene therapy for TMD

2005 - 2006 分化抑制因子Id2によるB細胞活性化・最終分化抑制機構の解析

2004 - 2005 Regulation of the Class Switch Recombination

2004 - 2005 Molecular analysis of Wnt, Shh-Ptch signaling in Ameloblastoma

2004 - 2004 分化抑制因子Id2によるB細胞活性化・最終分化抑制機構の解析

2002 - 2003 Molecular Analysis in Temporomandibular disorder

2002 - 2003 The roles of E2A and Id2 in class switch recombination

2002 - 2003 SNPを用いた顎変形症における遺伝要因のゲノム解析

2001 - 2002 ヒト顎関節円板・滑膜病変に対するANK遺伝子を用いた遺伝子診断法の開発

2000 - 2001 リンパ球の遺伝情報変換過程におけるDNAポリメレースβの機能解析

1999 - 1999 抗体のクラススイッチに先行して誘導されるGermline転写産物の機能解析

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Papers (75)：

V Ravi, A Murashima-Suginami, H Kiso, Y Tokita, C L Huang, K Bessho, J Takagi, M Sugai, Y Tabata, K Takahashi. Advances in tooth agenesis and tooth regeneration. Regenerative therapy. 2023. 22. 160-168
Sayaka Mishima, Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Jun-Ichiro Jo, Ryuji Uozumi, Yukiko Nambu, Boyen Huang, Hidemitsu Harada, et al. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice. Scientific Reports. 2021. 11. 1
A. Murashima-Suginami, H. Kiso, Y. Tokita, E. Mihara, Y. Nambu, R. Uozumi, Y. Tabata, K. Bessho, J. Takagi, M. Sugai, et al. Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling. Science Advances. 2021. 7. 7. eabf1798-eabf1798
Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata, Kazuhisa Bessho. Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy. INFLAMMATION AND REGENERATION. 2020. 40. 1
Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, et al. Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020. 140. 4. 838-+

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MISC (53)：

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Patents (2)：

Books (3)：

Lectures and oral presentations (7)：

Mitochondrial function in cell fate determination of activated B cells.
(Consortium of Biological Sciences 2017 2017)
ミトコンドリア機能による活性化B細胞運命決定機構
(日本鉄バイオサイエンス学会学術集会プログラム・抄録集 2015)
Mitochondrial function regulates heme oxygenase-1 expression through modulating ability of heme synthesiss
(8th International Conference on Heme Oxygeneses, BioIron & Stress 2014)
B cell-fate determination by mitochondrial ROS via inhibition of heme synthesis
(The 87th Annual Meeting of the Japanese Biochemical Society 2014)
ミトコンドリアによる活性化B細胞運命決定機構の解析-ヘム合成能制御による分化決定-
(日本生化学会大会(Web) 2014)

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