Art

J-GLOBAL ID：201402234624537176   Reference number：14A1451426

SYNTHESIS OF 7-AMINO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES BASED ON THE REACTION OF 4-CHLORO-5-LITHIO-6-METHOXYPYRIMIDINES WITH 2-(ARYLMETHYLIDENE)PROPANEDINITRILES

2-(アリールメチリデン)プロパンジニトリル類と4-クロロ-5-リチオ-6-メトキシピリミジン類の反応に基づく7-アミノ-5,8-ジヒドロピリド[2,3-d]ピリミジン-6-カルボニトリル誘導体の合成

Author (6)： KOBAYASHI Kazuhiro (Tottori Univ., Tottori, JPN) ,  YUBA Shohei (Tottori Univ., Tottori, JPN) ,  TANIGUCHI Aina (Tottori Univ., Tottori, JPN) ,  INOUCHI Hiroki (Tottori Univ., Tottori, JPN) ,  HIYOSHI Hidetaka (Ihara Chemical Ind. Co., Ltd., Tokyo, JPN) ,  UMEZU Kazuto (Ihara Chemical Ind. Co., Ltd., Tokyo, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 89  Issue： 11  Page： 2611-2618  Publication year： Nov. 01, 2014 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrile ,  *nitrogen heterocyclic compound ,  addition reaction ,  fluid flow ,  ether ,  aliphatic compound ,  aliphatic amine ,  tertiary amine
Semi thesaurus term： *carbonitrile ,  *Pyrimidines ,  reflux ,  conjugate addition

JST classification (1)： Pyrimidines  (CF07103W)

Substance index (16)： [α-[2-(Methylthio)-4-methoxy-6-chloropyrimidine-5-yl]benzyl]malononitrile ,  2-(Methylthio)-4-methoxy-5-(4-chlorophenyl)-7-amino-8-(4-methoxybenzyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-(4-methylphenyl)-7-amino-8-phenethyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-(4-methoxyphenyl)-7-amino-8-(4-methylbenzyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-phenyl-7-amino-8-(2-methoxyethyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-phenyl-7-amino-8-(4-chlorobenzyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-phenyl-7-amino-8-phenethyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-phenyl-7-amino-8-butyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-(Methylthio)-4-methoxy-5-phenyl-7-amino-8-benzyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  2-Methylthio-4-methoxy-6-chloropyrimidine ,  4-Methoxy-5-phenyl-7-amino-8-butyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  4-Methoxy-5-phenyl-7-amino-8-benzyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile ,  Dimethyl ether ,  LDA (reagent) ,  Triethylamine ,  Benzylidenemalononitrile

Reference (5)：

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Terms in the title (4)： プロパンジニトリル ,  ピリミジン ,  カルボニトリル ,  誘導体