Art

J-GLOBAL ID：201402235646660342   Reference number：14A0273221

Valproic Acid, a Histone Deacetylase Inhibitor, Decreases Proliferation of and Induces Specific Neurogenic Differentiation of Canine Adipose Tissue-Derived Stem Cells

ヒストンデアセチラーゼ阻害剤のバルプロ酸はイヌ脂肪組織由来幹細胞の増殖を減少し特異的神経形成分化の誘起する

Author (12)： KURIHARA Yasuhiro (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  SUZUKI Takehito (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  SAKAUE Motoharu (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  MURAYAMA Ohoshi (School of Life and Environmental Sci., Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  MIYAZAKI Yoko (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  ONUKI Atsushi (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  AOKI Takuma (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  SAITO Miyoko (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  FUJII Yoko (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  HISASUE Masaharu (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  TANAKA Kazuaki (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN) ,  TAKIZAWA Tatsuya (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara 252-5201, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 76  Issue： 1  Page： 15-23 (J-STAGE)  Publication year： 2014 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibitor ,...
Semi thesaurus term： Histone Deacetylase Inhibitors ,...

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JST classification (3)： Dogs,cats  (FD06010P) ,  Medical care and clinical equipment of animals  (FE01020U) ,  Other animal diseases  (FE02060T)

Substance index (1)： Valproic acid

Reference (39)：

• 1. Case, J., Horvath, T. L., Howell, J. C., Yoder, M. C., March, K. L. and Srour, E. F. 2005. Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells. Ann. N. Y. Acad. Sci. 1044: 183-200.
• 2. Chung, C. S., Fujita, N., Kawahara, N., Yui, S., Nam, E. and Nishimura, R. 2013. A comparison of neurosphere differentiation potential of canine bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells. J. Vet. Med. Sci. 75: 879-886.
• 3. De Ugarte, D. A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P. A., Zhu, M., Dragoo, J. L., Ashjian, P., Thomas, B., Benhaim, P., Chen, I., Fraser, J. and Hedrick, M. H. 2003. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174: 101-109.
• 4. Deng, W., Obrocka, M., Fischer, I. and Prockop, D. J. 2001. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem. Biophys. Res. Commun. 282: 148-152.
• 5. Dicker, A., Le Blanc, K., Astrom, G., van Harmelen, V., Gotherstrom, C., Blomqvist, L., Arner, P. and Ryden, M. 2005. Functional studies of mesenchymal stem cells derived from adult human adipose tissue. Exp. Cell Res. 308: 283-290.

Terms in the title (8)： ヒストンデアセチラーゼ阻害剤 ,  バルプロ酸 ,  イヌ ,  脂肪組織由来幹細胞 ,  増殖 ,  神経形成 ,  分化 ,  誘起