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J-GLOBAL ID：201402238209522142   Reference number：14A0774930

Colestimide improves glycemic control via hepatic glucose production in db/db mice

コレスチミドはdb/dbマウスにおいて肝グルコース産生を通して血糖コントロールを改善する

Author (6)： YAMAKAWA Tadashi (Dep. of Endocrinology and Diabetes, Yokohama City Univ. Medical Center, Yokohama, JPN) ,  OGIHARA Kikumi (Dep. of Pathology, Coll. of Environmental Health, Azabu Univ., Sagamihara, JPN) ,  UTSUNOMIYA Hirotoshi (The Dep. of Pathology, Wakayama Medical Univ., Wakayama, JPN) ,  MURAOKA Tomonori (Kannaiekimae clinic, Yokohama, JPN) ,  KADONOSONO Kazuaki (Dep. of Ophthalmology, Yokohama City Univ. Medical Center, Yokohama, JPN) ,  TERAUCHI Yasuo (Dep. of Endocrinology and Metabolism, Yokohama City Univ. School of Medicine, Yokohama, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 61  Issue： 5  Page： 425-436 (J-STAGE)  Publication year： 2014 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *anticholesteremic agent ,...
Semi thesaurus term： insulin resistance ,...

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JST classification (4)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Metabolism and nutrition of sugar(=glucide)  (EJ02035H) ,  Metabolism and nutrition of lipids  (EJ02034Q) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (1)： Cholic acid

Reference (43)：

• 1. Gupta S, Stravitz RT, Dent P, Hylemon PB (2001) Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 276: 15816-15822.
• 2. Qiao L, Han SI, Fang Y, et al. (2003) Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23: 3052-3066.
• 3. Kawamata Y, Fujii R, Hosoya M, et al. (2003) A G protein-coupled receptor responsive to bile acids. J Biol Chem 278: 9435-9440.
• 4. Maruyama T, Miyamoto Y, Nakamura T, et al. (2002) Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 298: 714-719.
• 5. Makishima M, Okamoto AY, Repa JJ, et al. (1999) Identification of a nuclear receptor for bile acids. Science 284: 1362-1365.

Terms in the title (5)： コレスチミド ,  Db ,  マウス ,  肝グルコース産生 ,  血糖コントロール