Art

J-GLOBAL ID：201402241302564417   Reference number：14A1197385

DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction

DOK7遺伝子療法は,神経筋接合部の欠損に特徴づけられるマウス病態モデルを改善させる

Author (11)： ARIMURA Sumimasa (Univ. Tokyo, Tokyo, JPN) ,  OKADA Takashi (National Center of Neurology and Psychiatry, Tokyo, JPN) ,  TEZUKA Tohru (Univ. Tokyo, Tokyo, JPN) ,  CHIYO Tomoko (National Center of Neurology and Psychiatry, Tokyo, JPN) ,  KASAHARA Yuko (National Center of Neurology and Psychiatry, Tokyo, JPN) ,  YOSHIMURA Toshiro (Nagasaki Univ. School of Health Sci., Nagasaki, JPN) ,  MOTOMURA Masakatsu (Nagasaki Inst. Applied Sci., Nagasaki, JPN) ,  YOSHIDA Nobuaki (Univ. Tokyo, Tokyo, JPN) ,  BEESON David (Univ. Oxford, Oxford, GBR) ,  TAKEDA Shin'ichi (National Center of Neurology and Psychiatry, Tokyo, JPN) ,  YAMANASHI Yuji (Univ. Tokyo, Tokyo, JPN)
Material： Science
Volume： 345  Issue： 6203  Page： 1505-1508  Publication year： Sep. 19, 2014 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *gene therapy ,  neuromuscular junction ,  *neuropathy ,  *neuromuscular disease ,  *gene ,  mouse(animal) ,  motor nerve ,  skeletal muscle ,  neural transmission ,  *genetic variation ,  *myasthenia ,  adeno-associated virus ,  *strengthening ,  *lifetime extension ,  autosome ,  hereditary disease ,  muscular dystrophy ,  motor capacity
Semi thesaurus term： *Myoneural disorders ,  *DOK7遺伝子 ,  *muscle strength buildup ,  Muscular Dystrophy, Emery-Dreifuss ,  *Motor Activity

JST classification (4)： Basic neurology  (GN01020W) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Basic therapeutics  (GC03012A) ,  Gene manipulation  (EC02050B)

Terms in the title (4)： 遺伝子療法 ,  神経筋接合部 ,  欠損 ,  マウス病態モデル