Art

J-GLOBAL ID：201402244482927767   Reference number：14A0413485

Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase

ウシおよびブタ線維芽細胞は変異型サイクリン依存性キナーゼ4,サイクリンD,およびテロメラーゼの発現によって無傷の核型で不死化する

Author (8)： DONAI Kenichiro (Graduate School of Agricultural Sci., Tohoku Univ., 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, JPN) ,  KIYONO Tohru (Div. of Virology, National Cancer Center Res. Inst., 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JPN) ,  EITSUKA Takahiro (Fac. of Applied Life Sciences, Niigata Univ. of Pharmacy and Applied Life Sciences, 265-1, Higashijima, Akiha-ku ...) ,  GUO Yijie (Graduate School of Agricultural Sci., Tohoku Univ., 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, JPN) ,  KURODA Kengo (Graduate School of Agricultural Sci., Tohoku Univ., 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, JPN) ,  SONE Hideko (Environmental Exposure Res. Section, Center for Environmental Risk Res., National Inst. for Environmental Studies ...) ,  ISOGAI Emiko (Graduate School of Agricultural Sci., Tohoku Univ., 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, JPN) ,  FUKUDA Tomokazu (Graduate School of Agricultural Sci., Tohoku Univ., 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, JPN)
Material： Journal of Biotechnology  (Reviews in Molecular Biotechnology)
Volume： 176  Page： 50-57  Publication year： Apr. 20, 2014 
JST Material Number： A0456C  ISSN： 0168-1656  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *cattle ,  *Sus scrofa domesticus ,  *fibroblast ,  cyclin-dependent kinase ,  *Cyclins ,  Telomerase ,  gene expression ,  *Karyotype ,  *cell immortalization ,  cultured cell ,  cell ,  database ,  *Cell Cycle ,  transduction ,  velocity ,  Cell Proliferation ,  cell aging ,  turnover ,  G1 ,  DNA synthetic period ,  Cyclin D ,  Cyclin-Dependent Kinase 4 ,  doubling rate ,  *Genetic Variation ,  *cell cycle regulator ,  *domestic animal ,  *Artiodactyla ,  serine-threonine kinase ,  *Proteins ,  molecular genetic phenomenon ,  *differentiation (biology) ,  *developmental physiology
Semi thesaurus term： *variation(biology) ,  *Bos taurus ,  cell bank ,  *cell cycle regulatory factor ,  turnover ,  *immortalization

JST classification (2)： Gene manipulation  (EC02050B) ,  Cell and tissue culture methods  (EA03040R)

Terms in the title (11)： ウシ ,  ブタ ,  線維芽細胞 ,  変異型 ,  サイクリン依存性キナーゼ4 ,  サイクリンD ,  テロメラーゼ ,  発現 ,  無傷 ,  核型 ,  不死化