Art

J-GLOBAL ID：201402255752169489   Reference number：14A0124074

Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal

心筋細胞のユビキチン化増加とG蛋白質シグナル伝達のクロストーク:GqシグナルによるGs抑制へのRic-8Bの関与

Author (9)： JENIE Riris I (Nara Inst. Sci. and Technol., Nara, JPN) ,  JENIE Riris I (Universitas Gadjah Mada, Yogyakarta, IDN) ,  NISHIMURA Motoki (Nara Inst. Sci. and Technol., Nara, JPN) ,  FUJINO Mika (Kyushu Univ., Fukuoka, JPN) ,  NAKAYA Michio (Kyushu Univ., Fukuoka, JPN) ,  MIZUNO Norikazu (Nara Inst. Sci. and Technol., Nara, JPN) ,  TAGO Kenji (Nara Inst. Sci. and Technol., Nara, JPN) ,  KUROSE Hitoshi (Kyushu Univ., Fukuoka, JPN) ,  ITOH Hiroshi (Nara Inst. Sci. and Technol., Nara, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 18  Issue： 12  Page： 1095-1106  Publication year： Dec. 2013 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *ubiquitination ,...
Semi thesaurus term： Gq protein ,...

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JST classification (3)： Receptors on cell membrane  (EF04030C) ,  Heart  (EJ04020D) ,  Cardiovascular system diseases  (GJ03000C)

Substance index (1)： cAMP

Reference (41)：

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• Afshar, K., Willard, RS., Colombo, K., Johnston, C.A., McCudden, Siderovski, D.P. & Gönczy, P. (2004) RIC-8 is required for GPR-1/2-dependent Gα function during asymmetric division of C. elegans embryos. Cell 119, 219-230.
• Akhter, S.A., Luttrell, L.M., Rockman, H.A., Iaccarino, G., Lefkowitz, R.J. & Koch, WJ. (1998) Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280, 574-577.
• Akhter, S.A., Milano, C.A., Shotwell, K.F., Cho, M.C., Rockman, H.A., Lefkowitz, RJ. & Koch, WJ. (1997) Transgenic mice with cardiac overexpression of α_1B-adrenergic receptors. In vivo α₁-adrenergic receptor-mediated regulation of β-adrenergic signaling. J. Biol. Chem. 272, 21253-21259.
• Chan, P.Y., Gabay, M., Wright, F.A. & Tall, G.G. (2011) Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. J. Biol. Chem. 286, 19932- 19942.

Terms in the title (6)： 心筋細胞 ,  ユビキチン化 ,  G蛋白質 ,  シグナル伝達 ,  クロストーク ,  シグナル