Art

J-GLOBAL ID：201402269504722300   Reference number：14A0698440

Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice

日本の生薬(漢方薬)の防風通聖散はマウスにおける非アルコール性脂肪肝炎の進行を減弱する

Author (14)： ONO Masafumi (Kochi Medical School, Dep. of Gastroenterology and Hepatology, Kohasu, 783-8505, Nankoku, Kochi, JPN) ,  OGASAWARA Mitsunari (Kochi Medical School, Dep. of Gastroenterology and Hepatology, Kohasu, 783-8505, Nankoku, Kochi, JPN) ,  HIROSE Akira (Kochi Medical School, Dep. of Gastroenterology and Hepatology, Kohasu, 783-8505, Nankoku, Kochi, JPN) ,  MOGAMI Sachiko (Tsumura & Co., Tsumura Res. Laboratories, Ibaraki, JPN) ,  OOTAKE Nobuhiro (Tsumura & Co., Tsumura Res. Laboratories, Ibaraki, JPN) ,  ARITAKE Kosuke (Osaka Bioscience Inst., Dep. of Molecular Behavioral Biology, Osaka, JPN) ,  HIGUCHI Takuma (Sci. Res. Center, Kochi Medical School, Lab. of Molecular Biology, Kochi, JPN) ,  OKAMOTO Nobuto (Kochi Medical School, Dep. of Gastroenterology and Hepatology, Kohasu, 783-8505, Nankoku, Kochi, JPN) ,  SAKAMOTO Shuji (Sci. Res. Center, Kochi Medical School, Lab. of Molecular Biology, Kochi, JPN) ,  YAMAMOTO Masahiro (Tsumura & Co., Tsumura Res. Laboratories, Ibaraki, JPN) ,  URADE Yoshihiro (Osaka Bioscience Inst., Dep. of Molecular Behavioral Biology, Osaka, JPN) ,  SAIBARA Toshiji (Kochi Medical School, Dep. of Gastroenterology and Hepatology, Kohasu, 783-8505, Nankoku, Kochi, JPN) ,  OBEN Jude A. (Univ. Coll. London, Inst. for Liver and Digestive Health, London, GBR) ,  OBEN Jude A. (Guy’s and St. Thomas’ Hospital, Dep. of Gastroenterology and Hepatology, London, GBR)
Material： Journal of Gastroenterology  (J Gastroenterol)
Volume： 49  Issue： 6  Page： 1065-1073  Publication year： Jun. 2014 
JST Material Number： Z0748A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： weight-reducing substance ,...

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JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Liver  (EJ06060J) ,  Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (1)： Aurothioglucose

Reference (37)：

• Ioannou GN, Boyko EJ, Lee SP. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002. Am J Gastroenterol. 2006;101:76-82.
• James O, Day C. Non-alcoholic steatohepatitis: another disease of affluence. Lancet. 1999;353:1634-6.
• Guha IN, Parkes J, Roderick P, Chattopadhyay D, Cross R, Harris S, et al. Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European liver fibrosis panel and exploring simple markers. Hepatology. 2008;47:455-60.
• Hioki C, Yoshimoto K, Yoshida T. Efficacy of bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clin Exp Pharmacol Physiol. 2004;31:614-9.
• Yamakawa J, Ishigaki Y, Takano F, Takahashi T, Yoshida J, Moriya J, et al. The Kampo medicines Orengedokuto, Bofutsushosan and Boiogito have different activities to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles. Biol Pharm Bull. 2008;31:2083-9.

Terms in the title (7)： 日本 ,  生薬 ,  漢方薬 ,  防風通聖散 ,  マウス ,  非アルコール性脂肪肝炎 ,  減弱