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J-GLOBAL ID：201402287315281660   Reference number：14A1173530

Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma

滑液膜肉腫における,SS18-SSXによる血管内皮成長因子作用の変動と複合血管内皮成長因子およびケモカイン(CXCのモティーフ)受容体4を標的とした療法

Author (10)： WAKAMATSU Toru (Dep. of Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan; Dep. of Orthopedics ...) ,  NAKA Norifumi ,  SASAGAWA Satoru ,  TANAKA Takaaki ,  TAKENAKA Satoshi ,  ARAKI Nobuhito ,  UEDA Takafumi ,  NISHIZAWA Yasuko ,  YOSHIKAWA Hideki ,  ITOH Kazuyuki
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 105  Issue： 9  Page： 1124-1134  Publication year： Sep. 2014 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *connective tissue tumor ,...
Semi thesaurus term： Receptors, CXCR4 ,...

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JST classification (4)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of musculoskeletal system  (GG04000A) ,  Receptors on cell membrane  (EF04030C) ,  Cytokines  (EB08090G)

Substance index (1)： Ifosfamide

Reference (42)：

• De Leeuw B, Balemans M, Weghuis DO, van Kessel AG. Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. Hum Mol Gene 1995; 4: 1097–9.
• Crew AJ, Clark J, Fisher C et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 1995; 14: 2333–40.
• Tsuji S, Hisaoka M, Morimitsu Y et al. Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Am J Pathol 1998; 153: 1807–12.
• Takenaka S, Ueda T, Naka N et al. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep 2008; 19: 467–76.
• Palmerini E, Staals EL, Alberghini M et al. Synovial sarcoma. Cancer 2009; 115: 2988–98.

Terms in the title (6)： 滑液膜肉腫 ,  血管内皮成長因子 ,  ケモカイン ,  受容体 ,  標的 ,  療法