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J-GLOBAL ID：201402288754298672   Reference number：14A0062707

抗体医薬品の溶液物性

Author (3)： UCHIYAMA SUSUMU (大阪大 大学院工学研究科) ,  KRAYUKHINA Elena (ユーメディコ) ,  NODA MASANORI (ユーメディコ)
Material： 薬剤学  (Journal of Pharmaceutical Science and Technology, Japan)
Volume： 74  Issue： 1  Page： 12-18  Publication year： Jan. 01, 2014 
JST Material Number： G0234A  ISSN： 0372-7629  CODEN： YAKUA  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *molecular targeting drug ,...
Semi thesaurus term： Tween80 ,...

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JST classification (1)： Physical pharmacy  (GY01012A)

Reference (10)：

• 1) H. Nishi, M. Miyajima, H. Nakagami, M. Noda, S. Uchiyama, K. Fukui, Phase separation of an IgG1 antibody solution under a low ionic strength condition, Pharm. Res., 27, 1348-1360 (2010).
• 2) S. Saito, J. Hasegawa, N. Kobayashi, T. Tomitsuka, S. Uchiyama, K. Fukui, Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities, Pharm. Res., 30, 1263-1280 (2013).
• 3) A. H. Elcock, J. A. McCammon, Calculation of weak protein-protein interactions: the pH dependence of the second virial coefficient, Biophys. J., 80, 613-625 (2001).
• 4) S. Saito, J. Hasegawa, N. Kobayashi, N. Kishi, S. Uchiyama, K. Fukui, Behavior of monoclonal antibodies: relation between the second virial coefficient (B (2)) at low concentrations and aggregation propensity and viscosity at high concentrations, Pharm. Res., 29, 397-410 (2012).
• 5) C. Lehermayr, H. C. Mahler, K. Mäder, S. J. Fischer, Assessment of net charge and protein-protein interactions of different monoclonal antibodies, J. Pharm. Sci., 100, 2551-2562 (2011).

Terms in the title (2)： 抗体医薬品 ,  溶液物性