Art

J-GLOBAL ID：201402294413959328   Reference number：14A0044557

Gene-modified T-cell Therapy Using Chimeric Antigen Receptor

キメラ抗原受容体(CAR)を用いた遺伝子改変T細胞療法

Author (1)： NAKAZAWA YOZO (信州大学医学部小児医学講座)
Material： 信州医学雑誌  (Shinshu Medical Journal)
Volume： 61  Issue： 4  Page： 197-203 (J-STAGE)  Publication year： 2013 
JST Material Number： G0594A  ISSN： 0037-3826  CODEN： SIZAA7  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human ,...
Semi thesaurus term： T lymphocyte ,...

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JST classification (1)： Immunotherapy for tumors  (GE03035B)

Reference (23)：

• 1) Cruz CR, Hanley PJ, Liu H, Torrano V, Lin YF, Arce JA, Gottschalk S, Savoldo B, Dotti G, Louis CU, Leen AM, Gee AP, Rooney CM, Brenner MK, Bollard CM, Heslop HE : Adverse events following infusion of T cells for adoptive immunotherapy : a 10-year experience. Cytotherapy 12 : 743-749, 2010
• 2) Leen AM, Rooney CM, Foster AE : Improving T cell therapy for cancer. Annu Rev Immunol 25 : 243-265, 2007
• 3) Eshhar Z, Waks T, Gross G, Schindler DG : Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A 90 : 720-724, 1993
• 4) Rossig C, Brenner MK : Genetic modification of T lymphocytes for adoptive immunotherapy. Mol Ther 10 : 5-18, 2004
• 5) Dotti G, Savoldo B, Brenner M : Fifteen years of gene therapy based on chimeric antigen receptors : “are we nearly there yet?”. Hum Gene Ther 20 : 1229-1239, 2009

Terms in the title (2)： キメラ抗原受容体 ,  遺伝子改変T細胞療法