Art

J-GLOBAL ID：201402295868608406   Reference number：14A1147526

Efficacy and Safety of Sugammadex (Org 25969) in Reversing Deep Neuromuscular Block Induced by Rocuronium or Vecuronium in Japanese Patients

スガマデクスナトリウム(MK-8616,Org25969)の筋弛緩拮抗作用-深い筋弛緩状態からの回復-

Author (14)： TAKEDA JUNZO (慶応大 医 麻酔学) ,  TAKEDA JUNZO (東京医療セ) ,  IWASAKI HIROSHI (旭川医大 麻酔・蘇生学) ,  OTAGIRI TETSUTARO (信州大 医 麻酔・蘇生学) ,  OTAGIRI TETSUTARO (JA長野厚生連 北信総合病院) ,  KATO TAKASUMI (浜松医大 医 麻酔・蘇生学) ,  SHINGU KO (関西医大 医 麻酔科) ,  OBARA HIDEFUMI (神戸大 大学院医学研究科 外科系 麻酔科学分野) ,  OBARA HIDEFUMI (公立浜坂病院) ,  NAKATSUKA HIDEKI (岡山大 病院 麻酔科蘇生科) ,  NAKATSUKA HIDEKI (川崎医大 麻酔・集中治療医学2) ,  TOMIYAMA YOSHINOBU (徳島大 医・歯 病院 手術部) ,  KASABA TOSHIHARU (宮崎大 医 麻酔生体管理学) ,  KASABA TOSHIHARU (函館市医師会 函館市医師会病院 麻酔科)
Material： 麻酔  (Japanese Journal of Anesthesiology)
Volume： 63  Issue： 10  Page： 1083-1088  Publication year： Oct. 10, 2014 
JST Material Number： F0838A  ISSN： 0021-4892  CODEN： MASUA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *skeletal muscle active agent ,...
Semi thesaurus term： RCT ,...

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JST classification (2)： Clinical application of drugs acting on skeletal muscle  (GW04050Z) ,  General anesthesia  (GC05020R)

Substance index (3)： Sugammadex ,  Rocuronium ,  Vecuronium

Reference (6)：

• Jones RK, Caldwell JE, Brull SJ, Soto RG. Reversal of profound rocuronium-induced blockade with sugammadex : a randomized comparison with neostigmine. Anesthesiology 2008 ; 109 : 816-24.
• Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide : synthesis and structure-activity relationships. J Med Chem 2002 ; 45 : 1806-16.
• Bom A, Bradley M, Cameron K, Clark JK, van Egmond J, Feilden H, et al. A novel concept of reversing neuromuscular block : chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed 2002 ; 41 : 266-70.
• Geldner G, Niskanen M, Laurila P, Mizikov V, Hübler M, Beck G, et al. A randomized controlled trial comparing sugammadex and neostigmine at different depth of neuromuscular blockade in patients undergoing laparoscopic surgery. Anaesthesia 2012 ; 67 : 991-8.
• Groudine SB, Soto R, Lien C, Drover D, Roberts K. A randomized, dose-finding, Phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block. Anesth Analg 2007 ; 104 : 555-62.

Terms in the title (4)： スガマデクスナトリウム ,  筋弛緩 ,  拮抗作用 ,  回復