Rchr
J-GLOBAL ID：201501023750260840   Update date: Apr. 09, 2025

Yamayoshi Asako

ヤマヨシ アサコ | Yamayoshi Asako
Affiliation and department：
Institute of Science Tokyo (Tokyo Institute of Technology) Department of Life Science and Engineering

About Institute of Science Tokyo (Tokyo Institute of Technology) Department of Life Science and Engineering


Job title： Professor
Other affiliations (1)：
Homepage URL  (2)： http://www.yamayoshi-lab.life.isct.ac.jp/ ,  http://www.yamayoshi-lab.life.isct.ac.jp/home-en/
Research field  (3)： Other ,  Biomedical engineering ,  Molecular biochemistry
Research keywords  (6)： 5-methylcytosine ,  exosome ,  Antibody-oligonucleotide conjugate ,  microRNA ,  Nucleic Acid Medicine ,  Nucleic Acid Chemistry
Research theme for competitive and other funds  (24)：
  • 2024 - 2026 Development of Novel Exosome-Hijacking Nucleic Acid Drugs for Treatment of Lung Cancers
  • 2022 - 2026 Development of novel light-triggerd genome editing system targeting retroviral infections
  • 2020 - 2025 Biophysical Chemistry for Material Symbiosis
  • 2020 - 2025 Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems
  • 2020 - 2025 Biophysical Chemistry for Material Symbiosis
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Papers (87)：
  • Yu Mikame, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi. Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides. Communications chemistry. 2025. 8. 1. 18-18
  • Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, et al. Publisher Correction: Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry (Nature Communications, (2023), 14, 1, (7972), 10.1038/s41467-023-43714-0). Nature Communications. 2024. 15. 1
  • Kawakami Shigeru, Ishima Yu, Arima Hidetoshi, Yamayoshi Asako, Fumoto Shintaro. From the Past to the Future of Focus Group: Focus Group on Supramolecular Pharmaceutics. Journal of Pharmaceutical Science and Technology, Japan. 2024. 84. 2. 66-70
  • Yu Mikame, Nagisa Maekawa, Soichiro Kimura, Juki Nakao, Asako Yamayoshi. Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photo-Crosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates. Synlett. 2023
  • Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, et al. Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry. Nature communications. 2023. 14. 1. 7972-7972
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MISC (91)：
  • 中尾 樹希, 三瓶 悠, 山吉 麻子. ゲノムDNAを標的とした光駆動核酸の開発-特集 多様化するバイオテクノロジーと光技術. 光アライアンス / 光アライアンス編集委員会 編. 2023. 34. 10. 30-34
  • 三瓶悠, 山本剛史, 山吉麻子. 核酸医薬とゲノム編集技術. CLINICAL NEUROSCIENCE 「核酸医薬と神経疾患」. 2023. 41
  • Tsuyoshi Yamamoto, Asako Yamayoshi. 核酸医薬の物性制御による有効性・安全性へのアプローチ 〜核酸医薬との物質共生に向けて〜. Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System. 2022. 37. 2. 131-141
  • Asako Yamayoshi. 物質共生の観点からDDSを考える 〜「共生」と「非共生」の狭間で〜. Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System. 2022. 37. 2. 99-99
  • 中尾樹希, 山本剛史, 山吉麻子. Genome editing tools and oligonucleotide therapeutics. 実験医学. 2021. 39. 17
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Patents (11)：
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Books (14)：
  • 医薬品におけるDDS技術開発と製剤への応用
    株式会社 情報機構 2021
  • 実験医学増刊 Vol.39 No.17「核酸医薬 本領を発揮する創薬モダリティ」(横田隆徳/編)
    羊土社 2021
  • 核酸科学ハンドブック
    講談社 2020 ISBN:9784065207864
  • 医薬品開発における中分子領域(核酸医薬・ペプチド医薬品)での開発戦略
    情報機構 2019
  • 中分子医薬開発に資するペプチド・核酸・糖鎖の合成・高機能化技術
    ジーエムシー出版 2018 ISBN:9784781313207
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Lectures and oral presentations  (64)：
  • 人工核酸とファルマシア・シンバイオシス
    (日本薬学会第145年会 2025)
  • Novel Exosome-hijacking drug delivery system for Nucleic Acid Drugs
    (Japan-Korea Collaborative Symposium on Biologics & Nanomedicine 2025)
  • 光を用いて遺伝情報を書き換える
    (Nano Bio College 医工連携で花開く核酸医薬ヘルスケア 2025)
  • Material symbiosis: From immune regulation to emerging modality
    (53th Annual Meeting of the Japanese Society for Immunology 2024)
  • 光ゲノム編集を可能とする人工核酸の開発と物質共生
    (「ニューモダリティと有機合成化学」 第11回勉強会・有機合成化学協会 2024)
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Education (4)：
  • 2000 - 2003 Kyoto Institute of Technology Graduate School of Science and Engineering Department of Biomaterial Science
  • 1998 - 2000 Kyoto Institute of Technology Graduate School of Science and Engineering Polymer Chemistry
  • 1994 - 1998 Kyoto Institute of Technology Faculty of Textile Science Polymer Chemistry
  • 1990 - 1993 TOYONAKA SENIOR HIGH SCHOOL
Professional career (1)：
  • Ph.D. (Kyoto Institute of Technology)
Work history (11)：
  • 2024/10 - 現在 Institute of Science Tokyo Department of Life Science and Engineering Professor
  • 2024/05 - 現在 Nagasaki University Graduate School of Biomedical Sciences Professor
  • 2024/05 - 2024/09 Tokyo Institute of Technology Department of Life Science and Engineering Professor
  • 2018/03 - 2024/04 Nagasaki University Graduate School of Biomedical Sciences Professor
  • 2021/04 - 2022/03 Osaka University School of Engineering Specially Appointed Professor
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Committee career (10)：
  • 2023/06 - 現在 Journal of Controlled Release (Elsevier) Editorial Board
  • 2022/07 - 現在 日本DDS学会 評議員
  • 2022/04 - 現在 Japanese Society for Extracellular Vesicles Director
  • 2021/07 - 現在 日本ケミカルバイオロジー学会 世話人
  • 2020/09 - 現在 日本核酸化学会 役員 運営委員
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Awards (2)：
  • 2022/08 - Nucleic Acids Therapeutics Society of Japan Academic Award
  • 2021/10 - 長崎大学 第6回「長崎大学未来に羽ばたく女性研究者賞」 優秀女性研究者賞
Association Membership(s) (11)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  NUCLEIC ACID CHEMISTRY OF JAPAN ,  THE NUCLEIC ACID THERAPEUTIC SOCIETY OF JAPAN ,  THE SOCIETY OF POLYMER SCIENCE, JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  Oligonucleotide Therapeutic Society ,  Japanese Society for Extracellular Vesicles ,  American Chemical Society ,  THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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