Rchr
J-GLOBAL ID：201501029844998809
Update date: Jan. 31, 2024
Tanimizu Naoki
タニミズ ナオキ | Tanimizu Naoki
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
https://kaken.nii.ac.jp/d/r/00333386.ja.html
Research field (3)：
Experimental pathology
, Morphology, anatomy
, General surgery, pediatric surgery
Research keywords (30)：
3次元培養
, 胆管上皮細胞
, 肝臓
, 組織形成
, 胆管
, 肝前駆細胞
, 管腔構造
, 幹細胞
, 培養
, サンドウィッチ
, 細胞
, 上皮細胞
, チューブ構造
, 肝臓発生
, 形態形成
, サンドウィッチ培養
, 共培養
, 細胞移植
, 肝発生
, 小型肝細胞
, 肝組織形成
, 肝再生
, スキャフォールド
, サイトカイン
, 毛細胆管
, 組織化
, 成熟化
, CD44
, 類肝組織
, 癌細胞
Research theme for competitive and other funds (19)：
- 2020 - 2023 Establishment of hepatobiliary connection ex vivo
- 2018 - 2023 Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer
- 2018 - 2021 Renewal of severely damaged livers by activating hepatic progenitor cells
- 2017 - 2020 Translational research for clinical apply using liver stem cells from cell banking
- 2017 - 2019 In vitro reconstruction of hepatic tissue
- 2017 - 2019 Effects of aging on the lineage plasticity of hepatocytes
- 2016 - 2019 The lineage plasticity fo mature hepatocytes during liver injury and regeneration
- 2014 - 2017 Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program
- 2014 - 2017 Hepatic stem cells transplantation activates the growth of intrinsic hepatic progenitor cells in recipient rat livers.
- 2014 - 2016 Research for the establishment of human hepatocytic progenitor cells
- 2013 - 2016 Role of liver stem/progenitor cells in development and regeneration
- 2013 - 2016 Fundamental Researches for the Application of Human Small Hepatocytes in Clinical Treatment
- 2012 - 2015 Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids
- 2012 - 2014 胆管をモデルとした、管腔構造の発達とチューブ構造形成を制御するメカニズムの解明
- 2012 - 2014 Development of the liver lobule-type culture device
- 2010 - 2011 Molecular mechanisms regulating epithelial morphogenesis during the development of bile ducts
- 2009 - 2011 Basic research for the production of human hepatocytes and the transplantation of hepatic tissues
- 2005 - 2009 Mechanism of liver development
- 2007 - 2008 Analysis of molecular mechanisms governing tubular morphogenesisof hepatic bile ducts using three dimensional culture
Show all
Papers (46)：
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Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka. CINC-2 and miR-199a-5p in exosomes secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration. 2023
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Yuta Koui, Misao Himeno, Yusuke Mori, Yasuhiro Nakano, Eiko Saijou, Naoki Tanimizu, Yoshiko Kamiya, Hiroko Anzai, Natsuki Maeda, Luyao Wang, et al. Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling. Stem cell reports. 2021. 16. 12. 3050-3063
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Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, et al. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nature communications. 2021. 12. 1. 3390-3390
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Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka. Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers. Stem cell research & therapy. 2021. 12. 1. 312-312
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Naoki Tanimizu, Norihisa Ichinohe, Hiromu Suzuki, Toshihiro Mitaka. Prolonged oxidative stress and delayed tissue repair exacerbate acetaminophen-induced liver injury in aged mice. Aging. 2020. 12. 19. 18907-18927
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MISC (9)：
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T. Mizuguchi, Y. Ichinohe, Y. Nakmaura, T. Shibata, N. Tanimizu, Y. Kikkawa, T. Mitaka, K. Hirata. UPDATE OF REGENERATIVE MEDICINE OF THE HEPATIC STEM CELLS. WOUND REPAIR AND REGENERATION. 2014. 22. 1. A1-A1
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小川 貴穂, 三輪 隆博, 谷水 直樹, 門谷 裕一, 水口 徹, 平田 公一, 野水 基義, 三高 俊広, 吉川 大和. 肝細胞癌における細胞接着分子ルテランの放出メカニズムの解明. 日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集. 2013. 45回・60回. 125-125
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水口 徹, 吉川 大和, 谷水 直樹, 一戸 義久, 中村 幸雄, 川本 雅樹, 目黒 誠, 野水 基義, 三高 俊広, 平田 公一. PD-6-1 肝細胞癌における細胞外マトリックスの分子環境 : ラミニンα鎖と受容体ルテランによる分子機序(PD パネルディスカッション,第113回日本外科学会定期学術集会). 日本外科学会雑誌. 2013. 114. 2. 242-242
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水口 徹, 吉川 大和, 谷水 直樹, 一戸 義久, 中村 幸雄, 川本 雅樹, 目黒 誠, 野水 基義, 三高 俊広, 平田 公一. PD-6-1 肝細胞癌における細胞外マトリックスの分子環境 : ラミニンα鎖と受容体ルテランによる分子機序(PD パネルディスカッション,第113回日本外科学会定期学術集会). 日本外科学会雑誌. 2013. 114. 2
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TANIMIZU Naoki, MITAKA Toshihiro. Tissue morphogenesis of liver epithelial cells. Seikagaku. The Journal of Japanese Biochemical Society. 2012. 84. 8. 658-665
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Professional career (1)：
Work history (1)：
- 2009 - 2013 Sapporo Medical University School of Medicine
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