Hagihara Yoshihisa

ハギハラヨシヒサ | Hagihara Yoshihisa

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50357761.ja.html

Research field (3)： Biophysics , Biomaterials , Biomedical engineering

Research keywords (19)：生物発光 , フォールディング , 細胞毒性 , 蛋白質工学 , iPS細胞 , ペプチド , 構造機能相関 , 機能 , リプログラミング因子 , 膜融合 , 転写因子 , α-ヘリックス , タンパク質 , 核酸の構造 , 細胞 , 動態 , 組織工学 , 蛋白質導入 , 受精

Research theme for competitive and other funds (7)：

2020 - 2023 Establishment of innovative development scheme of anti-cancer antibody
2020 - 2023 免疫刺激によるシングルドメイン抗体の親和性成熟と抗原抗体複合体の物性変化の解明
2016 - 2019 Development of visualizing system of microRNA dynamism
2016 - 2018 The effect of payload conjugates on VHH antibody
2014 - 2018 Elucidation of the molecular mechanism involved in mammalian gamete fusion

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Papers (133)：

Kyohei Kuroda, Shun Tomita, Hazuki Kurashita, Masashi Hatamoto, Takashi Yamaguchi, Tomoyuki Hori, Tomo Aoyagi, Yuya Sato, Tomohiro Inaba, Hiroshi Habe, et al. Metabolic implications for predatory and parasitic bacterial lineages in activated sludge wastewater treatment systems. Water Research X. 2023. 100196-100196
Tomonari Matsuda, Yoko Akazawa-Ogawa, Lilian-Kaede Komaba, Norihiko Kiyose, Nobuo Miyazaki, Yusaku Mizuguchi, Tetsuo Fukuta, Yuji Ito, Yoshihisa Hagihara. Prediction of antigen-responding VHH antibodies by tracking the evolution of antibody along the time course of immunization. Frontiers in immunology. 2023. 14. 1335462-1335462
Rie Sonoi, Yoshihisa Hagihara. Quantitative understanding of HepaRG cells during drug-induced intrahepatic cholestasis through changes in bile canaliculi dynamics. Pharmacology Research & Perspectives. 2022. 10. 3
Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, et al. Breakdown of supersaturation barrier links protein folding to amyloid formation. Communications Biology. 2021. 4. 1
Mototada Shichiri, Noriko Ishida, Yoshinori Aoki, Taisuke Koike, Yoshihisa Hagihara. Stress-activated leukocyte 12/15-lipoxygenase metabolite enhances struggle behaviour and tocotrienols relieve stress-induced behaviour alteration. Free Radical Biology and Medicine. 2021. 175. 171-183

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MISC (49)：

赤澤陽子, 松田知成, 宮崎誠生, 清瀬紀彦, 伊東祐二, 萩原義久. The predictions of high affinity single domain VHH antibody through repeated immunizations. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
松田知成, 大橋真也, 赤澤陽子, 藤井康太, 近藤雄紀, SHEN Shang, 針谷爽代花, 柳瀬楓, 坂中克行, 溝脇尚志, et al. Development of innovative antibody screening method by tracing evolution of antibody. 日本環境変異原ゲノム学会大会プログラム・要旨集. 2021. 50th
梅野彩, 七里元督, 堀江祐範, 萩原義久, 橋本芳子, 片岡正俊, 吉田康一, 福井敏樹. 新規バイオマーカー群を用いた糖尿病リスク評価モデルの検証. 人間ドック. 2016. 31. 2. 286-286
七里元督, 石田規子, 萩原義久, 久米愛子, 鈴木宏志. 霊長類へのプロブコールの投与による血漿中α-トコフェロールおよび脂質酸化物の変動. ビタミン. 2016. 90. 4. 188-188
董金華, 七里元督, 柴田貴広, 内田浩二, 吉田康一, 萩原義久, 上田宏. Open Sandwich ELISA法によるリノール酸酸化物13-(E,E)-HODEの検出. 日本蛋白質科学会年会プログラム・要旨集. 2016. 16th

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Patents (17)：

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Work history (1)：

2012 - National Institute of Advanced Industrial Science and Technology

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