Tadokoro Takashi

タドコロタカシ | Tadokoro Takashi

Affiliation and department：

Research field (3)： Functional biochemistry , Molecular biology , Biophysics

Research keywords (7)：蛋白質工学 , 蛋白質間相互作用 , 安定性 , 熱力学的解析 , 抗体 , カロリメトリー , 表面プラズモン共鳴

Research theme for competitive and other funds (3)：

2024 - 2027 高機能化抗体フラグメントの物理化学的特性解析
2020 - 2023 Molecular basis of multimeric antibody fragments towards the construction of highly functional antibody-drug conjugates
2016 - 2018 Structural study on the NKRP1A-LLT1 complex involved in the immune regulatory

Papers (48)：

Yuki Anraku, Shunsuke Kita, Taishi Onodera, Akihiko Sato, Takashi Tadokoro, Shiori Ito, Yu Adachi, Ryutaro Kotaki, Tateki Suzuki, Jiei Sasaki, et al. Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants. Communications biology. 2025. 8. 1. 483-483
Takashi Tadokoro, Harumi Tsuboi, Kota Nakamura, Tetsushi Hayakawa, Reo Ohmura, Izumi Kato, Masaki Inoue, Shin-Ichi Tsunoda, Sayaka Niizuma, Yukari Okada, et al. Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies. Protein science : a publication of the Protein Society. 2024. 33. 7. e5084
Kazuhide Miyamoto, Takashi Tadokoro, Atsushi Matsumoto. Unique E2-binding specificity of artificial RING fingers in cancer cells. Scientific reports. 2024. 14. 1. 2545-2545
Tsunehito Higashi, Haruka Handa, Yosuke Mai, Katsumi Maenaka, Takashi Tadokoro. Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages. Journal of pharmacological sciences. 2023. 153. 1. 22-25
Hiroki Tanaka, Shinya Hagiwara, Daiki Shirane, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Miho Hishinuma, Katsuyuki Chida, Kasumi Sasaki, et al. Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA. ACS nano. 2023. 17. 3. 2588-2601

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MISC (65)：

喜多俊介, 染谷太陽, 安楽佑樹, 田所高志, 田所高志, 小野寺大志, 安達悠, 森山彩野, 湯本航平, 橋口隆生, et al. 新型コロナウイルスに対する中和抗体の小型化. 日本抗体学会学術大会プログラム・抄録集(Web). 2024. 3rd
楊一帆, 楊一帆, 田所高志, 中島孝平, 杉浦直樹, 森岡弘志, 前田直良, 小川美香子, 前仲勝実. 近赤外線光を活用した免疫療法による難治性がんに対する低分子抗体医薬品の開発. 日本蛋白質科学会年会(Web). 2024. 24th
宮内龍, 秋田穂, 日下裕規, 田所高志, 杉山成, 相羽俊彦, 相羽俊彦, 深瀬浩一, 村田道雄, 井貫晋輔, et al. CD1d-アミド型抗原複合体のX線結晶構造解析と示差走査熱量計による熱安定性解析. 日本結晶学会年会講演要旨集. 2024. 2024
石田知聖, 田所高志, 大村玲央, 冨田麻美, 杉山葵, 宮本和英, 前仲勝実. Preparation of scFv antibody for reducing side effect. 日本薬学会年会要旨集(Web). 2024. 144th
伊東詩織, 喜多俊介, 上村健太朗, 上村健太朗, 上村健太朗, 上村健太朗, 岩間湧希, 田所高志, 澤洋文, 澤洋文, et al. Structural basis for antiviral activity of a nucleoside analogue targeting dengue virus RNA-dependent RNA polymerase. 日本薬学会年会要旨集(Web). 2024. 144th

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Patents (2)：

Books (5)：

創薬研究のための相互作用解析パーフェクト : 低中分子・抗体創薬におけるスクリーニング戦略と実例、in silico解析、一歩進んだ分析技術まで
羊土社 2021 ISBN:9784758122566
Silkworm Biofactory: Silk to Biology
CRC Press 2018
Advanced Methods in Structural Biology
© Springer Japan 2016
C-Type Lectin Receptors in Immunity
© Springer Japan 2016
Protein Structure
InTech 2012

Lectures and oral presentations (3)：

Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI.
(International Symposium on Advanced Science and Biotechnology 2007 2007)
Thermolabile RNase HI from the mesophilic bacterium Shewanella oneidensis MR-1.
(9th International Conference on RIBONUCLEASE H 2006 2006)
Studies on a Cold-adaptation Mechanism of RNase HI from a Psychrotrophic Bacterium.
(8th International Conference on RIBONUCLEASE H 2004 2004)

Professional career (1)：

博士(工学) (大阪大学)

Work history (8)：

2024/04 - 現在山口東京理科大学薬学部薬学科准教授
2022/01 - 2024/03 山口東京理科大学薬学部薬学科講師
2015/05 - 2021/12 Hokkaido University Faculty of Pharmaceutical Sciences
2013/07 - 2015/04 Hokkaido University Faculty of Pharmaceutical Sciences
2008/06 - 2013/06 National Institutes of Health

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Committee career (4)：

2023/01 - 2023/12 日本結晶学会 2023年会実行委員
2021/04 - 2022/03 日本結晶学会 2021年会実行委員
2019/04 - 2020/03 生物物理学会北海道支部会計
2017 - 2017 日本ケミカルバイオロジー学会第12回年会プログラム委員

Association Membership(s) (6)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , PROTEIN SCIENCE SOCIETY OF JAPAN , 日本薬学会 , The Crystallographic Society of Japan , THE BIOPHYSICAL SOCIETY OF JAPAN

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