Rchr
J-GLOBAL ID:201501092487718022   Update date: Feb. 01, 2024

Shimura Tsutomu

シムラ ツトム | Shimura Tsutomu
Affiliation and department:
Job title: 上席主任研究官
Homepage URL  (1): https://kaken.nii.ac.jp/d/r/40463799.ja.html
Research field  (3): Environmental effects of chemicals ,  Environmental effects of radiation ,  Environmental impact assessment
Research keywords  (3): 放射線 ,  がん ,  放射線耐性
Research theme for competitive and other funds  (11):
  • 2023 - 2027 Elucidation of the mechanism of radiation-related tumors focusing on the tumor microenvironment
  • 2022 - 2027 幹細胞の可視化によるがん化プロセス解析マウスモデルを用いた放射線発がん機構の解明
  • 2020 - 2023 発がんにおける組織幹細胞の細胞競合を可視化する解析系の確立とその応用
  • 2018 - 2021 Study of biological effects of ionizing radiation on mitochondria
  • 2017 - 2020 Role of the tumor microenvironment on radiation-induced carcinogenesis
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Papers (76):
  • Tsutomu Shimura, Kenta Sunaga, Mayu Yamazaki, Nara Honoka, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response. International journal of radiation biology. 2024. 1-11
  • Tsutomu Shimura. Mitochondrial Signaling Pathways Associated with DNA Damage Responses. International journal of molecular sciences. 2023. 24. 7
  • Tsutomu Shimura, Rina Shiga, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria. GENES. 2023. 14. 1
  • Megumi Sasatani, Tsutomu Shimura, Kazutaka Doi, Elena Karamfilova Zaharieva, Jianxiang Li, Daisuke Iizuka, Shinpei Etoh, Yusuke Sotomaru, Kenji Kamiya. Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice: possible mechanisms of radiation tumorigenesis. Carcinogenesis. 2022. 44. 1. 105-118
  • Tsutomu Shimura, Rina Totani, Hyougo Ogasawara, Keiki Inomata, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2022. 99. 5. 769-778
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MISC (34):
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Work history (5):
  • 2012/04 - 現在 National Institue of Public Health Department of Environmental Health Chief Senior Researcher
  • 2007/08 - 2012/03 IDAC Department of Pathology Assistant Professor
  • 2007/04 - 2007/07 神戸大学バイオシグナル研究センター 学術推進研究員
  • 2006/11 - 2007/03 理化学研究所 ゲノム損傷応答ユニット 協力研究員
  • 2003/06 - 2006/10 National Institute of Health, National Cancer Institute Laboratory of Molecular Phamacology Visiting Fellow
Awards (5):
  • 2015/05 - 15th ICRR ICRR2015 Excellent Poster Award
  • 2010/10 - 日本放射線影響学会 奨励賞
  • 2010/03 - 財団法人 放射線影響協会 放射線影響研究奨励賞
  • 2005/01 - 学術振興会 海外特別研究員 (NIH)
  • 2003/04 - 上原記念生命科学財団 海外留学助成金
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