2018 - 2021 Study of biological effects of ionizing radiation on mitochondria
2017 - 2020 Role of the tumor microenvironment on radiation-induced carcinogenesis
2015 - 2018 The study on the low dose radiation on oxidative stress and cardiovascular systems on maice
2015 - 2017 Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblasts
2012 - 2015 Eradication of radioresistant cancer stem cells by inhibiting the AKT survival signaling pathway.
2012 - 2014 New developments in mitochondrial study to overcome
2009 - 2010 Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiation
Tsutomu Shimura, Kenta Sunaga, Mayu Yamazaki, Nara Honoka, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response. International journal of radiation biology. 2024. 1-11
Tsutomu Shimura. Mitochondrial Signaling Pathways Associated with DNA Damage Responses. International journal of molecular sciences. 2023. 24. 7
Tsutomu Shimura, Rina Shiga, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria. GENES. 2023. 14. 1
Megumi Sasatani, Tsutomu Shimura, Kazutaka Doi, Elena Karamfilova Zaharieva, Jianxiang Li, Daisuke Iizuka, Shinpei Etoh, Yusuke Sotomaru, Kenji Kamiya. Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice: possible mechanisms of radiation tumorigenesis. Carcinogenesis. 2022. 44. 1. 105-118
Tsutomu Shimura, Rina Totani, Hyougo Ogasawara, Keiki Inomata, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama. Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2022. 99. 5. 769-778